PMID: 6983556Jan 1, 1982Paper

Efforts to enhance survival of limb allografts by prior administration of whole blood in rats using a new survival end-point

Journal of Microsurgery
K S BlackD W Furnas

Abstract

Injecting whole blood into the recipient before surgery can significantly prolong renal transplant survival in rats. Therefore, experiments were performed in rats to study the effects of prior administration of whole blood on the survival of limb allografts. Tests to quantitate survival of the allografts included monitoring the internal temperature of the leg, assaying serum creatine kinase levels, and testing for alloantibodies. Lewis recipients of (BN x LEW)F1 limb transplants that received 1 ml of BN or (BN x LEW)F1 whole blood before surgery had mean survival times that were longer compared with controls as measured by a 10 F change in temperature. In a test-retest experiment, decline of temperature proved to be a reliable quantitative determination of limb allograft survival since a difference of only 5.6% was observed in the mean number of days of graft survival between two separate groups of control Lewis recipients. Moreover, combined data demonstrated that control Lewis recipients of (BN x LEW)F1 limb allografts averaged 24.0 days of graft survival based on a 10 F decline in temperature with a 95% confidence interval of +/- 6.3 days. It is concluded that prior administration of whole blood can produce significant prolo...Continue Reading

References

Jun 1, 1978·The Journal of Surgical Research·R I Shapiro, F B Cerra
Aug 1, 1976·Transplantation·M PooleJ R Batchelor
Nov 1, 1975·Plastic and Reconstructive Surgery·T Harashina, H J Buncke
Apr 1, 1973·Transplantation·J W Fabre, P J Morris
Jun 28, 1968·Science·F P StuartF W Fitch
Mar 1, 1966·Plastic and Reconstructive Surgery·R M GoldwynR E Wilson
May 1, 1962·Radiology·J V SCHWIND
Oct 24, 1962·Annals of the New York Academy of Sciences·J V SCHWIND
Jan 1, 1965·The American Journal of Cardiology·W R VINCENT, E RAPAPORT

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Citations

Jan 1, 1994·Aesthetic Plastic Surgery·B A Shuster, L A Hoffman
Apr 10, 2007·Clinics in Plastic Surgery·Maria Siemionow, Galip Agaoglu
Sep 15, 2012·Microsurgery·David Manuel KiermeirMihai Adrian Constantinescu
Jun 29, 2007·Microsurgery·Maria Siemionow, Serdar Nasir
Mar 26, 2008·Annals of Plastic Surgery·Maria Siemionow, Serdar Nasir
Jan 1, 1987·Transplantation Reviews·E Towpik, J W Kupiec-Weglinski

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