Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue

Organic & Biomolecular Chemistry
Scott G StewartKeith A Stubbs

Abstract

Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or "click" synthetic methodology.

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Citations

Jan 1, 2016·Bioorganic & Medicinal Chemistry Letters·Jennifer M ChambersMark A Rizzacasa
Jul 16, 2019·MedChemComm·Christian SteinebachMichael Gütschow
Feb 27, 2018·The Journal of Organic Chemistry·Minh H NguyenAmos B Smith

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