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Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase

Annals of the New York Academy of Sciences

Jun 22, 2016

Qinggeng ZhuangChristopher M Hadad

Abstract

Aging is a dealkylation reaction of organophosphorus (OP)-inhibited acetylcholinesterase (AChE). Despite many studies to date, aged AChE cannot be reactivated directly by traditional pyridinium oximes. This review summarizes strategies that are potentially valuable in the treatment agai...read more

Mentioned in this Paper

Study
Whole Blood
Nonhuman primate
Oximes
ACHE
Cholinesterase Inhibitors, Reversible
Poisoning Aspects
Poisoning
Site
Pharmacologic Substance
Paper Details
References
  • References62
  • Citations1
12345...
  • References62
  • Citations1
1

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Efficacy of several oximes on organophosphorus poisoning

Nihon eiseigaku zasshi. Japanese journal of hygieneAugust 1, 1988
S YamanakaM Nishimura
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Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase

Annals of the New York Academy of Sciences

Jun 22, 2016

Qinggeng ZhuangChristopher M Hadad

PMID: 27327269

DOI: 10.1111/nyas.13124

Abstract

Aging is a dealkylation reaction of organophosphorus (OP)-inhibited acetylcholinesterase (AChE). Despite many studies to date, aged AChE cannot be reactivated directly by traditional pyridinium oximes. This review summarizes strategies that are potentially valuable in the treatment agai...read more

Mentioned in this Paper

Study
Whole Blood
Nonhuman primate
Oximes
ACHE
Cholinesterase Inhibitors, Reversible
Poisoning Aspects
Poisoning
Site
Pharmacologic Substance

Related Papers

QJM : Monthly Journal of the Association of Physicians

Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials

QJM : Monthly Journal of the Association of PhysiciansApril 30, 2002
M EddlestonN Buckley
Nihon eiseigaku zasshi. Japanese journal of hygiene

Efficacy of several oximes on organophosphorus poisoning

Nihon eiseigaku zasshi. Japanese journal of hygieneAugust 1, 1988
S YamanakaM Nishimura
Paper Details
References
  • References62
  • Citations1
12345...
  • References62
  • Citations1
1
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