PMID: 9438462Jan 23, 1998Paper

Effusion cytology of esophageal carcinoma

Cancer
A A RenshawS Swanson

Abstract

Effusions in patients with esophageal carcinoma have only been reported rarely, and the cytologic findings in these specimens have not been well described. The authors reviewed 70 effusion specimens from 45 patients with known esophageal carcinoma, 37 of whom underwent resection. Seventeen specimens were from 10 patients with squamous cell carcinoma; only 1 specimen contained malignant cells. Fifty-three specimens were from 35 patients with adenocarcinoma. Twenty-one specimens from 10 patients with adenocarcinoma contained malignant cells; these included 17 pleural, 2 pericardial, and 2 peritoneal fluids. Lymph node involvement at the time of resection was a significant risk factor for the development of a malignant effusion. The cytologic features were similar to those of other adenocarcinomas, but >50% of the specimens were hypocellular and neoplastic cells were rare. Three of 48 negative specimens contained markedly atypical mesothelial cells that were misinterpreted as possibly malignant; in each case the findings resolved over time. These cells were smaller and the chromatin more smudgy than in the neoplastic cells. Patients with positive effusions were significantly more likely to die of disease than those with a negative...Continue Reading

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Citations

Feb 6, 2010·World Journal of Gastroenterology : WJG·Takatsugu OidaSadao Amano
Jul 17, 2013·CytoJournal·Walid E KhalbussManon Auger
May 26, 1999·Annals of Surgical Oncology·S NatsugoeT Aikou
Sep 21, 2019·The Journal of Thoracic and Cardiovascular Surgery·Daniel L Miller

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