Efinaconazole 10% Topical Solution: Case Review of Onychomycosis Patients Who Were Completely Cured at Week 24

Skin Appendage Disorders
Boni E ElewskiTina Lin

Abstract

Clinical studies with topical onychomycosis agents typically involve daily application over 48 weeks. Some patients are cured earlier; however, individual data are limited. The aim of this study was to assess baseline demographics/disposition of onychomycosis patients completely cured at week 24 following daily efinaconazole treatment. We conducted a week-24 case review of 2 identical, multicenter, randomized, double-blind, vehicle-controlled studies on 1,655 patients with mild-to-moderate onychomycosis. Patients were randomized (3:1) to efinaconazole 10% solution or vehicle, once daily for 48 weeks, with a 4-week post-treatment follow-up. Complete cure was defined as 0% clinical involvement of the target toenail and mycological cure (negative KOH examination and fungal culture). Overall, 19 patients had clear nails (0% clinical involvement) at week 24, and 13 (68%) were completely cured. Patients were predominantly younger (17/19 aged <65 years), female (12/19), and with recent disease (6/12). No patient had disease recurrence over the subsequent 28 weeks. Complete cure appeared independent of baseline severity. Two patients with moderate disease had clear nails by week 12, and 1 experienced recurrence. Efinaconazole 10% topic...Continue Reading

References

May 20, 1998·International Journal of Dermatology·A K GuptaR Baran
Apr 4, 2007·Dermatologic Therapy·Justin J Finch, Erin M Warshaw
Nov 26, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·B Sigurgeirsson
Nov 28, 2012·Journal of the American Academy of Dermatology·Boni E ElewskiJason T Olin

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Citations

Nov 10, 2018·Expert Review of Anti-infective Therapy·Aditya K GuptaVincent Piguet
Nov 21, 2018·American Journal of Clinical Dermatology·Aditya K GuptaBianca Maria Piraccini
Jun 10, 2021·Expert Review of Anti-infective Therapy·Tracey C Vlahovic, Aditya K Gupta

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