Efinaconazole 10% topical solution for the topical treatment of onychomycosis of the toenail

Expert Review of Clinical Pharmacology
Shari R Lipner, Richard K Scher

Abstract

Efinaconazole 10% topical solution is a new antifungal therapy for the topical treatment of mild to moderate toenail onychomycosis. In vitro and in vivo data have shown significant antifungal activity against dermatophytes, Candida spp. and nondermatophyte molds, and its mechanism of action is through inhibition of fungal lanosterol 14α-demethylase. In two parallel, double-blind, randomized, controlled, Phase III trials, complete cure rates were 17.8 and 15.2%, respectively, and mycological cure rates were 55.2 and 53.4%, respectively, for efinaconazole 10% topical solution, which were superior to vehicle, with minimal adverse events. This drug profile reviews the most recent basic science and clinical data for efinaconazole in the treatment of toenail onychomycosis.

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Citations

Mar 14, 2018·Antimicrobial Agents and Chemotherapy·Ali Rezaei-MatehkolaeiHamid Badali
Jan 29, 2019·Expert Opinion on Pharmacotherapy·Shari R Lipner
Apr 3, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Aditya K GuptaBianca Maria Piraccini
Jul 1, 2018·Journal of the American Academy of Dermatology·Shari R Lipner, Richard K Scher
Jun 6, 2020·Journal of the American Academy of Dermatology·Claire R StewartShari R Lipner

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