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EFNB2 facilitates cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via the p53/p21 pathway and EMT

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie

Feb 10, 2020

Feng ZhuYi Miao

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PubMed

Abstract

Ephrin-2 (EFNB2) is expressed at abnormally high levels in some neoplasms, such as squamous cell carcinoma of the head and neck and colorectal cancer. Its overexpression is associated with the malignant progression of tumors. However, the expression of EFNB2 in pancreatic ductal adenoca...read more

Mentioned in this Paper

Squamous Cell Carcinoma
Colorectal Cancer
Research Study
Western Blotting
Tumor Tissue Sample
Protein Overexpression
Protein Expression
Epithelial to Mesenchymal Transition
P53 Signaling Pathway
Ki-67 Antigen
2
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EFNB2 facilitates cell proliferation, migration, and invasion in pancreatic ductal adenocarcinoma via the p53/p21 pathway and EMT

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie

Feb 10, 2020

Feng ZhuYi Miao

PMID: 32036221

DOI: 10.1016/j.biopha.2020.109972

Abstract

Ephrin-2 (EFNB2) is expressed at abnormally high levels in some neoplasms, such as squamous cell carcinoma of the head and neck and colorectal cancer. Its overexpression is associated with the malignant progression of tumors. However, the expression of EFNB2 in pancreatic ductal adenoca...read more

Mentioned in this Paper

Squamous Cell Carcinoma
Colorectal Cancer
Research Study
Western Blotting
Tumor Tissue Sample
Protein Overexpression
Protein Expression
Epithelial to Mesenchymal Transition
P53 Signaling Pathway
Ki-67 Antigen
2

Feeds With Similar Papers

Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma holds a significant mortality risk, largely due to its late diagnosis and ineffective chemotherapeutic response. This gastrointestinal malignancy offers a poor prognosis and the only potential cure is through surgical resection. Here are the latest discoveries pertaining to this disease.

p53 Pathway

p53 is a transcription factor that is involved in several cellular processes, including cell cycle arrest, cellular apoptosis, cell death and cell senescence. Mutations in the wild type p53 gene has been implicated in a significant number of cancers. Here is the latest research on p53 pathways.

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