EGF Receptor Inhibition Alleviates Hyperuricemic Nephropathy

Journal of the American Society of Nephrology : JASN
Na LiuShougang Zhuang

Abstract

Hyperuricemia is an independent risk factor for CKD and contributes to kidney fibrosis. In this study, we investigated the effect of EGF receptor (EGFR) inhibition on the development of hyperuricemic nephropathy (HN) and the mechanisms involved. In a rat model of HN induced by feeding a mixture of adenine and potassium oxonate, increased EGFR phosphorylation and severe glomerular sclerosis and renal interstitial fibrosis were evident, accompanied by renal dysfunction and increased urine microalbumin excretion. Administration of gefitinib, a highly selective EGFR inhibitor, prevented renal dysfunction, reduced urine microalbumin, and inhibited activation of renal interstitial fibroblasts and expression of extracellular proteins. Gefitinib treatment also inhibited hyperuricemia-induced activation of the TGF-β1 and NF-κB signaling pathways and expression of multiple profibrogenic cytokines/chemokines in the kidney. Furthermore, gefitinib treatment suppressed xanthine oxidase activity, which mediates uric acid production, and preserved expression of organic anion transporters 1 and 3, which promotes uric acid excretion in the kidney of hyperuricemic rats. Thus, blocking EGFR can attenuate development of HN via suppression of TGF-β1...Continue Reading

References

Jan 1, 1992·Journal of Molecular Evolution·X W WuC T Caskey
Mar 29, 2000·Biochemical and Biophysical Research Communications·H UchinoA Tsuji
May 2, 2001·Cell Biochemistry and Biophysics·S HayashiT Noguchi
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Hong HuaCatharine I Whiteside
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin FlamantJean-Claude Dussaule
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tohru UmekawaSaeed R Khan
Mar 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hélène FrançoisChristos Chatziantoniou
Sep 30, 2004·American Journal of Physiology. Renal Physiology·Rémon A M H Van AubelFrans G M Russel
Oct 21, 2004·Therapeutische Umschau. Revue thérapeutique·M A Hediger
Dec 22, 2004·Kidney International·Laura G Sánchez-LozadaJaime Herrera-Acosta
Mar 18, 2005·Physiology·Matthias A HedigerHitoshi Endou
May 10, 2005·Biochimica Et Biophysica Acta·Adriana Mónica TorresHitoshi Endou
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Tae Woo YooDong Geuk Keum
Jan 13, 2006·Kidney International·Youhua Liu
Dec 28, 2006·American Journal of Physiology. Renal Physiology·Laura G Sánchez-LozadaMartha Franco
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Yohannes HagosAndrew Bahn
Feb 7, 2007·Current Opinion in Rheumatology·Naohiko AnzaiHitoshi Endou
May 30, 2007·Seminars in Nephrology·Erwin P Böttinger
Oct 24, 2008·The New England Journal of Medicine·Daniel I FeigRichard J Johnson
Mar 24, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Magdalena MaderoVandana Menon
Jul 1, 2009·Arthritis and Rheumatism·Seo Young KimDaniel A Albert
Jan 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Diana I JalalJanet K Snell-Bergeon
Mar 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sarah D McDonaldPhilip J Devereaux
Oct 6, 2010·The Journal of Clinical Investigation·Amandine ViauFabiola Terzi
Mar 25, 2011·American Journal of Nephrology·Hiroo SonodaGenjiro Kimura
Sep 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yejin MokSun Ha Jee
Nov 19, 2011·Journal of the American Society of Nephrology : JASN·Jianchun ChenRaymond C Harris
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Ming JinXiao-Feng Yang
Mar 1, 2012·Journal of the American Society of Nephrology : JASN·Na LiuShougang Zhuang
Oct 13, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Diana I JalalGiovanni Targher

❮ Previous
Next ❯

Citations

Apr 26, 2016·Nature Reviews. Nephrology·Xiao-Ming MengHui Yao Lan
Jun 23, 2016·International Journal of Molecular Sciences·Feng Liu, Shougang Zhuang
Mar 16, 2017·Journal of Cellular Physiology·Yoshiaki YamanakaPeter C Amadio
Dec 19, 2018·American Journal of Hypertension·Stephanie CicaleseSatoru Eguchi
Dec 20, 2018·American Journal of Physiology. Renal Physiology·Yingfeng ShiNa Liu
Jul 5, 2016·Nature Reviews. Nephrology·Laura R HarskampEsther Meijer
Dec 17, 2017·Oncotarget·Liuqing XuNa Liu
Jul 21, 2020·BioMed Research International·Hong-Yong SuHua-Feng Liu
Jul 1, 2016·Physiological Reviews·Jianchun ChenRaymond C Harris
Jul 2, 2020·Drug Design, Development and Therapy·Xin WangHequn Zou
Oct 27, 2020·American Journal of Physiology. Renal Physiology·Xingying ChenShougang Zhuang
Dec 12, 2018·Current Medicinal Chemistry·Jing PanPing Fu
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jing PanPing Fu
Mar 6, 2021·Frontiers in Pharmacology·Chongxiang XiongShougang Zhuang
Mar 9, 2021·Frontiers in Physiology·Tingting LiShougang Zhuang
Jun 24, 2021·Journal of Food Science·Hongling LiHaitao Li
May 18, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Qian RenPing Fu
Aug 3, 2021·Frontiers in Pharmacology·Hao-Lu SunJuan Jin
Jul 7, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Chuanxi SunRenzhong Wan
Aug 6, 2021·International Immunopharmacology·Lan LiYanrong Lu
Sep 10, 2020·Kidney Diseases·Ling NieJinghong Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.