EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice.

Mucosal Immunology
Zhirong JiaMin Hong

Abstract

Claudin1 plays a critical role in maintaining the epithelial barrier, and mucus hypersecretion induced by epidermal growth factor receptor (EGFR) activation is a pivotal pathological feature of asthma. The relationship between claudin1 expression and mucus hypersecretion and EGFR activation is still poorly understood. In this report, we showed that claudin1 expression correlated with asthma stage, in both patients with asthma and in the house dust mite (HDM)-induced mouse asthma model. Claudin1 knockdown induced MUC5AC overexpression both in 16HBE cells and in mouse airways. In addition, claudin1 expression negatively correlated with asthma severity as demonstrated by significantly higher MUC5AC expression, more severe airway inflammation, and increased airway hyperreactivity in mouse lungs with claudin1 knockdown following HDM challenge. EGFR activation reduced claudin1 expression and increased MUC5AC expression, both in vitro and in vivo. Erlotinib alleviated murine allergic airway inflammation, restored claudin1 expression and decreased MUC5AC expression. These results suggest that EGFR activation-induced decreases in claudin1 promote goblet-cell metaplasia, and restoring claudin1 to maintain barrier integrity by EGFR antago...Continue Reading

References

Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·M AmishimaY Kawakami
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·K TakeyamaJ A Nadel
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C L OrdoñezJ V Fahy
Nov 20, 2001·Current Opinion in Pharmacology·J A Nadel, P R Burgel
Jan 19, 2002·The Journal of Allergy and Clinical Immunology·Riccardo PolosaDonna E Davies
Aug 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Fabio BucchieriDonna E Davies
Jul 11, 2003·Chest·Henry A JenkinsJoseph D Spahn
Jun 12, 2004·American Journal of Respiratory Cell and Molecular Biology·Christopher M EvansBurton F Dickey
Feb 3, 2006·The Journal of Clinical Investigation·Lauren Cohn
Jul 3, 2007·Experimental & Molecular Medicine·Gyu Young HurSe Hwa Yoo
Dec 13, 2007·The Journal of Allergy and Clinical Immunology·Stephen T Holgate
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·W I de BoerG J Braunstahl
Nov 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Lingxiang ZhuYin Chen
Dec 17, 2008·Current Opinion in Pulmonary Medicine·Christopher M EvansBurton F Dickey
Jan 6, 2009·Biochimica Et Biophysica Acta·Maria S Balda, Karl Matter
May 9, 2009·American Journal of Respiratory and Critical Care Medicine·Anh L InnesJohn V Fahy
May 12, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suil Kim, Jay A Nadel
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Yukinori EnomotoYoshimichi Okayama
Dec 3, 2010·The New England Journal of Medicine·John V Fahy, Burton F Dickey
Jan 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Timothy D Le CrasGurjit K Khurana Hershey
May 31, 2011·Respiratory Research·Ylermi Soini
Dec 14, 2011·Journal of Biomedicine & Biotechnology·Naoki Ichikawa-TomikawaHideki Chiba
Mar 6, 2012·Human Immunology·Michael LiuThallachallour Mohanakumar
Apr 17, 2013·Physiological Reviews·Dorothee Günzel, Alan S L Yu
May 2, 2013·The Journal of Allergy and Clinical Immunology·Michelle A HardymanJane E Collins
Jun 11, 2014·The Journal of Cell Biology·David J Erle, Dean Sheppard
Aug 3, 2014·The Journal of Allergy and Clinical Immunology·Steve N Georas, Fariba Rezaee
Oct 30, 2014·American Journal of Respiratory and Critical Care Medicine·Ronald G Crystal
Feb 18, 2015·Nature Communications·Christopher M EvansBurton F Dickey
Apr 18, 2015·Frontiers in Immunology·Vivek D Gandhi, Harissios Vliagoftis
Jan 20, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Liqiang SongYan Li
Sep 25, 2017·Allergology International : Official Journal of the Japanese Society of Allergology·Yasuhiro Gon, Shu Hashimoto

❮ Previous
Next ❯

Citations

May 5, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiaohan WeiXiaomei Tan
Jul 6, 2021·International Journal of Cell Biology·Manoj J MammenStanley A Schwartz
Aug 24, 2021·Journal of Asthma and Allergy·Xu ChenWenchun Xu

❮ Previous
Next ❯

Datasets Mentioned

BETA
GPL6480

Methods Mentioned

BETA
ELISA
biopsy
bronchoalveolar
transfection
transfections

Software Mentioned

Pro Plus
ChemiScope
IPP
GraphPad
Prism
Image

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Helen J HarrisJane A McKeating
International Journal of Cancer. Journal International Du Cancer
Jeng-Woei LeeYih-Chih Hsu
© 2021 Meta ULC. All rights reserved