EGFR and anti-EGFR nanobodies: review and update.

Journal of Drug Targeting
Jafar SharifiBahman Akbari

Abstract

Targeted therapy is one of the favourable methods used in cancer treatment. Several recombinant proteins and small-molecules used for this aim include monoclonal antibodies, antibody fragments and peptides. Nanobody (Nb) is a camelid antibody fragment that is very effective in targeted therapy. Recently, several anti-EGFR (epidermal growth factor receptor) Nbs have been developed and utilised for diagnosis and therapy of EGFR overexpressing tumours. Anti-EGFR Nbs are used in drug delivery systems, photodynamic therapy (PDT) and/or conjugated to other molecules such as quantum dots (QDs), nanoparticles, liposome, tumour penetration peptides, neural stem cells (NSCs) and chimeric antigen receptor T cells (CAR T cells). In this review, we discussed the structure and function of EGFR and Nb, the current status of EGFR targeting, and recent developments in anti-EGFR Nbs. To gain sound insight into the issue at hand, we focused on the most powerful anti-EGFR Nbs.

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Citations

Feb 23, 2021·Journal of Drug Targeting·Mohammad Reza KhirehgeshBahman Akbari
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nichole E M KaufmanMaria da Graça H Vicente
May 1, 2021·International Journal of Molecular Sciences·Sara S RinneVladimir Tolmachev
Jun 17, 2021·Cell and Tissue Research·Nicola WannerFriedrich Koch-Nolte

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