EGFR aptamer-conjugated liposome-polycation-DNA complex for targeted delivery of SATB1 small interfering RNA to choriocarcinoma cells

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jinhua DongJin Sun

Abstract

Choriocarcinoma is a highly aggressive and vascular cancer. The main treatment for choriocarcinoma is the chemotherapy associated with severe side effects. Therefore, the development of novel strategies to eliminate choriocarcinoma is crucial for increasing the health of women. SATB1 (special AT-rich sequence binding protein 1) participates in tissue-specific gene expression and higher-order chromatin organization, and could promote cancer progression and invasion. For the first time, we hereby demonstrated that the expression of SATB1 was increased by 19 folds in choriocarcinoma cells compared with the normal chorionic cell line, and inhibition of SATB1 expression could markedly inhibit the proliferation of choriocarcinoma cells. Then we developed the gene drug delivery system EGFR-LPDS (epidermal growth factor receptor aptamer-conjugated liposome-polycation-DNA complex loaded with SATB1 siRNA) to increase the delivery and therapeutic effect of SATB1 siRNA against choriocarcinoma cells. The results showed that EGFR-LPDS could specifically target choriocarcinoma cells, resulting in significant inhibition of SATB1 expression, growth inhibitory effect and apoptosis in EGFR over-expressing choriocarcinoma cells in vitro. Notably, ...Continue Reading

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Citations

Oct 1, 2019·Advanced Materials·Byungji KimMichael J Sailor
Jan 29, 2020·Nucleic Acid Therapeutics·Elena ZavyalovaAlexey Kopylov
May 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huan ChenXueyan Cao
Jul 25, 2019·Journal of Drug Targeting·İpek Eroğlu, Mamudu İbrahim
Jan 1, 2020·Pharmaceutics·Ana Paula Dinis Ano BomSotiris Missailidis
Dec 4, 2020·International Journal of Molecular Sciences·Zhaoying Fu, Jim Xiang
Jul 2, 2019·International Journal of Pharmaceutics·Marimuthu CitartanThean-Hock Tang
Mar 18, 2021·Journal of Liposome Research·Hanieh AbbasiSomayeh Handali
Sep 28, 2021·International Journal of Pharmaceutics·Phuoc Vinh NguyenEmilie Allard-Vannier

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