EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients

International Journal of Cancer. Journal International Du Cancer
Shi-Yi YangChien-Jen Chen

Abstract

We explored potential associations between genetic polymorphisms in genes related to DNA repair and detoxification metabolism and epidermal growth factor receptor (EGFR) mutations in a cohort of 410 never-smoking patients with lung adenocarcinoma. Multivariate-adjusted odds ratios (aORs) and corresponding 95% confidence intervals (CI) of EGFR mutation status in association with the genotypes of DNA repair and detoxification metabolism genes were evaluated using logistic regression analysis. We found an association between in-frame deletion in EGFR exon 19 and a single nucleotide polymorphism (SNP) rs1800566C/T located in NQO1 (aOR, 2.2 with 95% CI, 1.0-4.8) in female never-smokers. The SNP rs744154C/G in ERCC4 was also associated with the EGFR exon 19 in-frame deletion both in never-smokers (aOR, 1.7 with 95% CI, 1.0-3.0) and female never-smokers (aOR, 1.9 with 95% CI, 1.0-3.6). Although the association was marginally significant in multivariate logistic regression analysis, the A/A genotype of rs1047840 in EXO1 was associated with a 7.6-fold increase in the occurrence of the EGFR exon 19 in-frame deletion in female never-smokers. Moreover, risk alleles in NQO1, ERCC4 and EXO1 were associated with an increasing aOR of the EGFR ...Continue Reading

Associated Clinical Trials

Nov 23, 2015·Pan-Chyr Yang, MD, PhD

References

Jan 1, 1996·Annual Review of Pharmacology and Toxicology·J D Yager, J G Liehr
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C GoesslH K Schackert
May 18, 2001·Nature·J H Hoeijmakers
Jun 26, 2001·Environmental and Molecular Mutagenesis·Y W ChengH Lee
Mar 29, 2002·Journal of Cellular Physiology·Thomas M MartiOliver Fleck
Oct 23, 2002·Critical Reviews in Toxicology·Janne HukkanenHannu Raunio
Sep 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R HirschWilbur A Franklin
Sep 19, 2003·International Journal of Colorectal Disease·Wolfram KleinThomas Griga
Jan 2, 2004·Breast Cancer Research and Treatment·Francesmary ModugnoMarjorie Romkes
Jul 31, 2004·Science·Raffaella SordellaJeffrey Settleman
Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Aizen J MarrogiCurtis C Harris
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·David G KornguthErich M Sturgis
Jul 1, 2006·Science·Maria Teresa LandiBoris C Bastian
Dec 15, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Guangfu JinHongbing Shen
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daphne W BellDaniel A Haber
Jul 3, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jenifer L MarksWilliam Pao
Apr 11, 2009·Nature·Michael R StrattonP Andrew Futreal
Jul 18, 2009·International Journal of Cancer. Journal International Du Cancer·Tomoaki TanakaKoichi Hagiwara
Aug 5, 2009·Pharmacogenomics·Sarah R McWhinney, Howard L McLeod
Feb 24, 2010·Nature Reviews. Molecular Cell Biology·Simona NegriniThanos D Halazonetis
Mar 3, 2010·Mutagenesis·M Kirsch-VoldersD H Phillips
Jun 16, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hidetaka UramotoKosei Yasumoto
Nov 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomoya KawaguchiHidefumi Sasaki
Dec 3, 2010·The Journal of Pathology·William PaoZengliu Su
Feb 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shi-Yi YangChien-Jen Chen

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Citations

Sep 16, 2014·International Journal of Environmental Research and Public Health·Ahmet YilmazWeiqiang Zhao
Jan 18, 2016·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Javier RevolloVasily N Dobrovolsky

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