EGFR immunolabeling pattern may discriminate low-grade gliomas from gliosis.

Journal of Neuro-oncology
F Burel-VandenbosThierry Virolle

Abstract

Overexpression of epidermal growth factor receptor (EGFR) is common in gliomas. Gliomas are infiltrating tumors in which neoplastic glial cells can be intermingled with reactive glial cells, particularly in diffuse low-grade gliomas. As overexpression of EGFR has also been described in gliosis, it can be difficult to evaluate EGFR immunolabeling in diffuse low-grade gliomas because of this cell mix. We compared EGFR immunolabeling between gliosis and low-grade gliomas in order to identify distinctive criteria. We studied EGFR expression in 28 cases of gliosis and 39 diffuse low-grade gliomas (23 astrocytomas and 16 oligodendrogliomas). EGFR immunohistochemistry staining was performed on paraffin-embedded sections with a mouse monoclonal antibody (clone 2-18C9; Dako). Co-expression of EGFR with Olig2, Mib-1, and p53 was assessed in seven cases of low-grade gliomas using double immunolabeling. Then, EGFR immunostaining was blindly tested on 22 small specimens of indeterminate glial lesions provided by a reference neuropathological center. Two pathologists of our local center were asked to classify the lesions into diffuse low-grade glioma or gliosis according to the pattern of EGFR expression. Weak expression of EGFR was commonly...Continue Reading

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Citations

Jun 4, 2020·International Journal of Molecular Sciences·Christian H RouxEz-Zoubir Amri
Apr 16, 2014·Journal of Neuro-oncology·Daniel J BratUNKNOWN AANS/CNS Joint Guidelines Committee
Jun 14, 2012·Advances in Anatomic Pathology·Marie Rivera-Zengotita, Anthony T Yachnis
May 23, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Parsa ErfaniNadejda M Tsankova
Feb 19, 2020·Journal of Neuropathology and Experimental Neurology·Ekkehard HewerErik Vassella
Mar 14, 2014·Journal of Biochemistry·Mika HabuShosei Kishida
Feb 24, 2021·International Journal of Clinical Practice·Michael NwekeAdekunle Adesina

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