EGFR in limbo.

Cell
Michael J Eck, William C Hahn

Abstract

The epidermal growth factor receptor (EGFR) is normally activated by ligand-induced dimerization. Oncogenic mutations in EGFR promote activation in a largely ligand-independent manner. Shan et al. uncover a partially disordered state of EGFR kinase, providing evidence that oncogenic mutations counteract this intrinsic structural instability to promote dimerization and aberrant activation.

References

Aug 28, 2002·The Journal of Biological Chemistry·Jennifer StamosCharles Eigenbrot
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John C SokJennifer R Grandis
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Oct 16, 2010·Science·David E ShawWilly Wriggers

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