EGFR mutation status in a series of Turkish non-small cell lung cancer patients

Biomedical Reports
Gizem Calibasi-KocalYasemin Basbinar

Abstract

Epidermal growth factor receptor (EGFR) mutations are potential markers driving carcinogenesis, and may alter the response to EGFR tyrosine kinase inhibitors in patients with non-small cell lung cancer (NSCLC). The frequency of EGFR mutations in patients with NSCLC differs according to sex, smoking habits and regional-based ethnicity differences. The aim of the present study was to determine the frequency of EGFR mutations in Turkish patients with NSCLC to highlight the importance of regional differences, and their associations with patient characteristics. Genomic DNA was extracted from formalin-fixed and paraffin-embedded tumor tissue sections of 409 NSCLC patients. The most common EGFR mutations in exons 18, 19, 20 and 21 were detected using BioFilmChip-based microarray assay. The overall EGFR mutation frequency was 16.6%, and the highest mutation frequencies were observed in exon 19 (6.4%) and exon 21 (7.3%). There was a higher frequency of EGFR mutations in females compared with males and in never-smokers compared with smokers (both P≤0.05). These results were similar to other European population-based studies, but not consistent Middle-Eastern based studies. The present study may contribute to understanding the gradient f...Continue Reading

References

Mar 3, 2005·Journal of the National Cancer Institute·Hisayuki ShigematsuAdi F Gazdar
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yoshio TomizawaMasatomo Mori
Dec 20, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kenichi SudaTetsuya Mitsudomi
Sep 28, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Robert PirkerUNKNOWN European EGFR Workshop Group
Feb 7, 2012·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Michel P BihlLuigi Terracciano
Aug 17, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Marius Lund-IversenOdd Terje Brustugun
Mar 5, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Gizem CalibasiUgur Yilmaz
Mar 15, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Erminia MassarelliVassiliki Papadimitrakopoulou
Apr 12, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chong-Kin LiamTiffany Shi-Yeen Ng
Jun 1, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S DeardenD Blowers
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hassan ErrihaniIbrahim Elghissassi
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jan 1, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Markus D Siegelin, Alain C Borczuk
Aug 19, 2014·The Journal of Molecular Diagnostics : JMD·Grace W WeyantKeri J Donaldson
Nov 8, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yasushi YatabeTony Mok
Apr 15, 2015·Translational Lung Cancer Research·Ángel Artal CortésJorge Hernando Cubero
Dec 2, 2015·Oncology Letters·Eirini PapadopoulouGeorge Nasioulas
Jan 26, 2016·Molecular and Clinical Oncology·Abdul Rahman JaziehAhmed Gasmelseed
Nov 28, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hai-Yan TuYi-Long Wu
Aug 30, 2018·Nature Communications·Song WuYusuf A Hannun
Nov 15, 2018·Balkan Journal of Medical Genetics : BJMG·Z A HammoudehD Toncheva
Mar 28, 2019·Expert Review of Anticancer Therapy·Lara Kujtan, Janakiraman Subramanian
Jun 19, 2019·Translational Lung Cancer Research·Abhishek ShankarGoura Kishor Rath
Aug 6, 2019·Mayo Clinic Proceedings·Narjust DumaJulian R Molina
Sep 12, 2019·Frontiers in Oncology·Rintu Thomas, Zhang Weihua

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Eurasian Journal of Medicine
Sener TasdemirYusuf Ozkul
Asian Pacific Journal of Cancer Prevention : APJCP
Polina GervasNadezda Cherdyntseva
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Wolfgang SchuetteMichael Thomas
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Satu Mäki-NevalaSakari Knuutila
© 2022 Meta ULC. All rights reserved