EGFR Promoter Methylation, EGFR Mutation, and HPV Infection in Chinese Cervical Squamous Cell Carcinoma

Applied Immunohistochemistry & Molecular Morphology : AIMM
Wei ZhangJu Zhang

Abstract

Therapy strategy toward epidermal growth factor receptor (EGFR) inhibition in cervical cancer has been ongoing. EGFR promoter methylation status and EGFR tyrosine kinase inhibitor-sensitive mutations in cervical cancer may be significant for clinical outcome prediction using anti-EGFR treatment. In this study, EGFR tyrosine kinase inhibitor-sensitive mutations, EGFR exons 18, 19, and 21 mutations, were detected by sequencing in a total of 293 Chinese cervical squamous cell carcinoma tissue samples. EGFR promoter methylation status was detected by an EGFR asymmetric PCR and hybridization-fluorescence polarization assay and sequencing in 293 Chinese cervical squamous cell carcinoma tissue samples. High-risk human papillomavirus (HPV) genotypes in 293 Chinese cervical squamous cell carcinoma tissue samples were detected by an asymmetric GP5+/6+ PCR and hybridization-fluorescence polarization assay. No EGFR exons 18, 19, and 21 mutations were detected, EGFR promoter methylation status was identified in 98 samples, and HPV 16 infection was the first frequent HPV genotype. The methylated EGFR promoter was identified most frequently in cervical squamous cell carcinoma samples with HPV 16 infection (53.4%). Statistical significant diff...Continue Reading

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Citations

Jul 3, 2015·Oncology Reports·Xuesong SongWenjie Zhang
Feb 18, 2016·BioMed Research International·Bhornprom YoysungnoenSuthiluk Patumraj
Sep 12, 2020·The International Journal of Biological Markers·Hongwen YangLihua Long
Aug 12, 2016·International Journal of Oncology·Zhiqiang PengJunfang Zheng
Jun 1, 2018·International Journal of Genomics·Chunyang FengTianmin Xu
Nov 10, 2020·Current Opinion in Pharmacology·Dominik DiefenbachThomas Efferth

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Methods Mentioned

BETA
PCR
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Software Mentioned

BLAST

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