EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

Cell Cycle
Barry Jutten, Kasper M A Rouschop

Abstract

The epidermal growth factor receptor (EGFR) is amplified or mutated in various human epithelial tumors. Its expression and activation leads to cell proliferation, differentiation, and survival. Consistently, EGFR amplification or expression of EGFR variant 3 (EGFRvIII) is associated with resistance to conventional cancer therapy through activation of pro-survival signaling and DNA-repair mechanisms. EGFR targeting has successfully been exploited as strategy to increase treatment efficacy. Nevertheless, these targeting strategies have only been proven effective in a limited percentage of human tumors. Recent knowledge indicates that EGFR deregulated tumors display differences in autophagy and dependence on autophagy for growth and survival and the use of autophagy to increase resistance to EGFR-targeting drugs. In this review the dependency on autophagy and its role in mediating resistance to EGFR-targeting agents will be discussed. Considering the current knowledge, autophagy inhibition could provide a novel strategy to enhance therapy efficacy in treatment of EGFR deregulated tumors.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J WongB Vogelstein
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N SugawaV P Collins
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·T G BoultonG D Yancopoulos
Jan 15, 1997·The EMBO Journal·M A LemmonJ Schlessinger
Dec 2, 2000·Science·D J Klionsky, S D Emr
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R I NicholsonM E Harper
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Sep 5, 2002·Nature Reviews. Molecular Cell Biology·David E Levy, J E Darnell
Sep 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R HirschWilbur A Franklin
Nov 7, 2003·Genes, Chromosomes & Cancer·Ajay PanditaC David James
Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
Jan 7, 2004·Cancer Cell·Aimee L Edinger, Craig B Thompson
Apr 10, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Bradly G WoutersCostas Koumenis
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chris A LearnJohn H Sampson
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
May 4, 2005·The Journal of Cell Biology·Masaaki KomatsuTomoki Chiba
Jul 15, 2005·The New England Journal of Medicine·Frances A ShepherdUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 15, 2005·The New England Journal of Medicine·Ming-Sound TsaoFrances A Shepherd
Aug 16, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marianne NordsmarkJens Overgaard
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Miguel TaronTeresa Moran
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Oct 26, 2005·Cell Death and Differentiation·N Mizushima
Apr 21, 2006·Experimental Cell Research·Antonina Y AlexandrovaBoris P Kopnin
May 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hongbin JiKwok-Kin Wong
Aug 9, 2006·Nature Clinical Practice. Oncology·I Bernard Weinstein, Andrew K Joe
Nov 7, 2006·Trends in Cell Biology·Bryan Linggi, Graham Carpenter
Nov 23, 2006·The Journal of Biological Chemistry·Kyle A Rasbach, Rick G Schnellmann
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Mar 27, 2007·Nature Reviews. Cancer·Suzanne SchubbertGideon Bollag
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Alejandro Wolf-YadlinForest M White
May 22, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sherry A WepplerGuido Lammering
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher E PelloskiKenneth Aldape

❮ Previous
Next ❯

Citations

Feb 12, 2014·Seminars in Cell & Developmental Biology·Fenghua Zeng, Raymond C Harris
Feb 2, 2016·Trends in Cell Biology·Xiaojun TanRichard A Anderson
Jan 17, 2015·Cell·Xiaojun TanRichard A Anderson
Dec 17, 2015·Journal of Neuropathology and Experimental Neurology·Jantima TanboonDavid N Louis
Apr 3, 2014·The Journal of Investigative Dermatology·Patrick CampbellJohn A McGrath
Aug 20, 2015·Journal of Cancer Research and Clinical Oncology·Paloma Silva de SouzaRaquel Ciuvalschi Maia
Apr 11, 2015·Apoptosis : an International Journal on Programmed Cell Death·Abedul HaqueA R M Ruhul Amin
Apr 23, 2016·The Journal of Pathology·Susanne ScheiplAdrienne M Flanagan
Jul 29, 2017·Nature Reviews. Cancer·Jean M Mulcahy LevyAndrew Thorburn
Nov 20, 2018·Journal of Cellular Biochemistry·HongYan WangLiYuan Guo
Jul 17, 2014·EMBO Reports·Adi Abada, Zvulun Elazar
Nov 28, 2019·Molecular & Cellular Proteomics : MCP·Stamatia RontogianniMaarten Altelaar
Apr 15, 2017·Oncotarget·Kiran K VelpulaAndrew J Tsung
Jun 2, 2016·Oncotarget·Romaine I FernandoClaudia Palena
Aug 5, 2016·Oncotarget·Engeng ChenZhangfa Song
Mar 1, 2019·Marine Drugs·Ping LiuTaek-Jeong Nam
Sep 19, 2019·Cancers·Yoojung KwonDooil Jeoung
Dec 15, 2019·Cell Death and Differentiation·Jean M Mulcahy Levy, Andrew Thorburn
Sep 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Guan-Yu XiaoSandra L Schmid
Sep 12, 2019·Frontiers in Oncology·Rintu Thomas, Zhang Weihua
Dec 10, 2016·Frontiers in Oncology·Tom G KeulersKasper M A Rouschop
Apr 3, 2020·Journal of Translational Medicine·Xiaofei WangZhenfa Zhang
Mar 27, 2018·International Journal of Cancer. Journal International Du Cancer·Mopa Alina SooroPinghu Zhang
Sep 4, 2020·Cancers·Lydie M O BarbeauKasper M A Rouschop
Nov 19, 2020·International Journal of Molecular Sciences·Isabell GöttingJohann Matschke
Aug 9, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Don-Hong WangBryan M Burt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms