Egg-white and blood-serum proteins functioning by noncovalent interactions: studies by chemical modification and comparative biochemistry

Journal of Protein Chemistry
R E Feeney, D T Osuga

Abstract

Some of the more interesting and important proteins are those that function by forming associations or complexes with other substances. The structure-function relationships of three of these with very different substances are transferrins, which chelate metal ions; avian ovomucoids, which form complexes with proteolytic enzymes; and antifreeze glycoproteins, which interact at the ice-solution interface. Interrelating studies on the comparative biochemistry with studies using chemical modification have helped identify the side-chain groups of the proteins involved in function as well as to be useful for studies on general protein chemistry. The most strongly associated interaction is the chelation of iron by transferrin, with an association constant of approximately 10(21); tyrosines, histidines, and sometimes aspartate are involved. For ovomucoids, individual substratelike residues such as lysine are involved in a Michaelis-like complex, and association constants are as high as 10(10). By contrast, the antifreeze glycoproteins appear to function by a polymeric interaction at the surface of ice, with a much weaker association.

References

Mar 6, 1979·Biochemistry·Y YehR E Feeney
Nov 27, 1979·Biochemistry·K F GeogheganR E Feeney
Jan 1, 1978·Advances in Protein Chemistry·R E Feeney, Y Yeh
Oct 1, 1979·International Journal of Peptide and Protein Research·R G WalshR E Feeney
Jan 1, 1979·International Journal of Peptide and Protein Research·K FretheimR E Feeney
Mar 21, 1978·Biochemistry·T B RogersR E Feeney
May 3, 1978·Biochimica Et Biophysica Acta·F Franks, E R Morris
Mar 1, 1977·Journal of Agricultural and Food Chemistry·A S NashefR E Feeney
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T M RoseJ P Brown
Jul 1, 1985·International Journal of Peptide and Protein Research·W S WongR E Feeney
Jan 1, 1985·The Journal of Membrane Biology·W S May, P Cuatrecasas
Jan 1, 1987·Archives of Biochemistry and Biophysics·M H PennerR E Feeney
May 4, 1987·European Journal of Biochemistry·R R Crichton, M Charloteaux-Wauters
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B F AndersonE N Baker
Jan 1, 1986·Annual Review of Biophysics and Biophysical Chemistry·R E FeeneyY Yeh
Feb 1, 1987·International Journal of Peptide and Protein Research·R E Feeney
Apr 1, 1968·Biochemistry·F C Greene, R E Feeney
Jan 1, 1972·Die Naturwissenschaften·R E FeeneyD T Osuga
Jan 19, 1971·Biochimica Et Biophysica Acta·W H LiuR E Feeney
Jan 16, 1971·Chemistry & Industry·R G Spickett
Mar 20, 1968·Archives of Biochemistry and Biophysics·D T Osuga, R E Feeney
Jan 1, 1966·Archives of Biochemistry and Biophysics·M M Simlot, R E Feeney
Aug 12, 1966·Biochemical and Biophysical Research Communications·G FeinsteinR E Feeney
Apr 1, 1967·Biochemistry·S K Komatsu, R E Feeney
Feb 1, 1967·Biochemistry·R HaynesR E Feeney
Aug 1, 1984·Archives of Biochemistry and Biophysics·C A BushR E Feeney
Feb 29, 1984·Biochemical and Biophysical Research Communications·G UzanA Kahn
Jan 1, 1983·Annual Review of Physiology·A L DeVries
May 15, 1984·Analytical Biochemistry·W S WongR E Feeney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.