Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study

Clinical Rheumatology
Kevin J RuffBarry W Ritz


Natural Eggshell Membrane (NEM(R)) is a new novel dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy articular cartilage and the surrounding synovium. The randomized, multicenter, double-blind, placebo-controlled Osteoarthritis Pain Treatment Incorporating NEM(R) clinical study was conducted to evaluate the efficacy and safety of NEM(R) as a treatment for pain and stiffness associated with osteoarthritis of the knee. Sixty-seven patients were randomly assigned to receive either oral NEM(R) 500 mg (n = 34) or placebo (n = 33) daily for 8 weeks. The primary endpoint was the change in overall Western Ontario and McMasters Universities (WOMAC) Osteoarthritis Index as well as pain, stiffness, and function WOMAC subscales measured at 10, 30, and 60 days. The clinical assessment was performed on the intent-to-treat population. Supplementation with NEM(R) produced an absolute rate of response that was statistically significant (up to 26.6%) versus placebo at all time points for both pain and stiffness, but was not significantly improved for function and overall WOMAC scores, although trending toward improvement. Rapid responses were seen for mean pain subscores (15.9% ...Continue Reading


Jul 1, 1984·Developmental Biology·M WongR Stern
Jan 1, 1980·Connective Tissue Research·B C Starcher, G S King
Nov 11, 1999·Biochimica Et Biophysica Acta·M AkagawaKyozo Suyama
Sep 12, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·M HinckeY Nys
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Gregory P GebaVioxx, Acetaminophen, Celecoxib Trial (VACT) Group
Apr 23, 2003·Poultry Science·T NakanoL Ozimek
Feb 1, 1962·The Biochemical Journal·J R BAKER, D A BALCH
Feb 17, 2005·The New England Journal of Medicine·Robert S BresalierAdenomatous Polyp Prevention on Vioxx (APPROVe) Trial Investigators
Feb 17, 2005·The New England Journal of Medicine·Scott D SolomonAdenoma Prevention with Celecoxib (APC) Study Investigators
Feb 17, 2005·The New England Journal of Medicine·Nancy A NussmeierKenneth M Verburg
Mar 19, 2005·BMJ : British Medical Journal·Florence TubachB Giraudeau
Apr 23, 2005·The Cochrane Database of Systematic Reviews·T E TowheedG Wells
Sep 22, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Lonnie WenJohn Cornell
Jan 27, 2006·The Cochrane Database of Systematic Reviews·T E TowheedG Wells
Feb 14, 2006·Pain·Jörn Lötsch, Gerd Geisslinger
Feb 24, 2006·The New England Journal of Medicine·Daniel O CleggH James Williams
Oct 28, 2006·European Journal of Pain : EJP·Henry J McQuay, Andrew Moore
Jan 1, 2008·Arthritis and Rheumatism·Reva C LawrenceNational Arthritis Data Workgroup


Jan 25, 2014·Advances in Colloid and Interface Science·Partha Sarathi Guru, Sukalyan Dash
Dec 17, 2014·International Journal of Molecular Sciences·Yaning ShiYoshinori Mine
Jan 17, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kevin J RuffAlexander G Schauss
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Mahesh Kumar Sah, Subha Narayan Rath
Mar 12, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Shin-Ichi KonnoHiroyuki Enomoto
Nov 20, 2018·Journal of Digestive Diseases·You Ming LiNational Workshop on Fatty Liver and Alcoholic Liver Disease, Chinese Society of Hepatology, Chinese Medical Association; Fa
Mar 9, 2017·Proteome Science·N C RathJ O Lay

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