PMID: 9181550Apr 1, 1997Paper

Eggshells are shaped by a precise spatio-temporal arrangement of sequentially deposited macromolecules

Matrix Biology : Journal of the International Society for Matrix Biology
M S FernándezJ L Arias


The avian eggshell is a composite bioceramic which is formed by a controlled interaction of an organic and an inorganic phase. The organic phase contains, among other constituents, type X collagen and proteoglycans, mainly keratan and dermatan sulfate. Understanding the principles governing the synthesis and temporo-spatial distribution of such macromolecules, and their influence on the organization of the crystalline phase, is an essential aspect of establishing the biological basis of the quality of eggshell, both as an embryonic chamber and as a natural food package. In the present study, we have examined the process of eggshell formation by immunohistochemistry, scanning electron microscopy and energy dispersive X-ray microanalysis. Precise sites and timing of secretion were established for the deposition of particular macromolecules. Type X collagen is detected at the very first moment of shell membrane formation. The appearance of keratan sulfate coincides with the appearance of mammillae, while dermatan sulfate is deposited later, coincident with shell matrix deposition. We propose that keratan sulfate, due to its precise localization, temporal appearance and calcium-binding affinity, relates to the maintenance of calciu...Continue Reading


May 1, 1978·The Journal of Nutrition·S BaumgartnerR M Leach
Oct 1, 1992·Archives of Biochemistry and Biophysics·J I AriasA I Caplan
Feb 28, 1992·Science·A H HeuerD H Thompson
Nov 1, 1991·Matrix : Collagen and Related Research·J I AriasA I Caplan
Jan 1, 1991·Connective Tissue Research·J I AriasA I Caplan
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L W Fisher, H Schraer
Aug 1, 1984·Biophysical Journal·R M Sharp, H Silyn-Roberts
Dec 1, 1980·Archives of Biochemistry and Biophysics·L W Fisher, H Schraer
Feb 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·T M WuA H Heuer
Dec 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·M PinesA Bar
Aug 3, 1963·Nature·D S ROBINSON, N R KING


Nov 18, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J C Marxen, W Becker
Sep 12, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·M T HinckeY Nys
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·J E DennisA I Caplan
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·M Soledad FernandezJ I Arias
Nov 5, 1997·British Poultry Science·J I AriasE Kessi
Aug 28, 1999·British Poultry Science·M PanheleuxY Nys
Feb 8, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M T HinckeM D McKee
Jan 7, 2014·PloS One·Cristianne M M CordeiroM T Hincke
Dec 17, 2014·Journal of the Royal Society, Interface·Branislav IgicMatthew D Shawkey
May 20, 2009·Cellular and Molecular Life Sciences : CMLS·Megan L H Rose, M T Hincke
Jan 15, 2015·Journal of Proteomics·Megan Rose-MartelM T Hincke
May 1, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Young Wan HaYeong Shik Kim
Sep 15, 2004·Journal of Structural Biology·M S FernándezJ L Arias
Aug 16, 2015·Journal of Structural Biology·M S FernándezJ L Arias
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Mahesh Kumar Sah, Subha Narayan Rath
Nov 28, 2018·Korean Journal for Food Science of Animal Resources·Ji-Ae Park, Sea-Hwan Sohn
Feb 14, 2021·BMC Molecular and Cell Biology·J GautronM T Hincke
Jul 26, 2008·Chemical Reviews·José L Arias, María S Fernández
Jun 22, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Qun DongNa Wang
Sep 19, 2014·The Journal of Experimental Biology·Steven J PortugalPhillip Cassey

Related Concepts

Dermatan Sulfate
Egg Shell
Keratan Sulfate
Electron Microscopy
Proteoglycan Type H

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