Egr-1 identifies neointimal remodeling and relates to progression in human pulmonary arterial hypertension

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Diederik van der FeenRolf M F Berger

Abstract

Pulmonary arterial hypertension (PAH) is hallmarked by the development of neointimal lesions. The transcription factor Egr-1 seems to play a critical role in neointimal formation in experimental PAH and was identified as a putative target for intervention. In this study we investigated whether Egr-1 is also associated with neointimal-type vascular remodeling in different forms of human PAH or pulmonary hypertension. Using immunohistochemistry, we studied Egr-1 expression specifically in a wide morphologic spectrum of pulmonary arteries in the lung tissue of 72 patients with different forms and stages of PAH, specifically idiopathic PAH (n = 18), advanced-stage congenital heart disease‒associated PAH (PAH-CHD) (n = 21), early-stage PAH-CHD (n = 19) and non-neointimal hypoxic pulmonary hypertension (PH) (n = 4), and controls (n = 10). In PAH patients, pulmonary vascular expression of Egr-1 protein was abundant, whereas it was sporadic in non-neointimal (hypoxic) PH patients and controls. In PAH-CHD, protein expression was more pronounced in patients with advanced vascular lesions compared to those with less advanced lesions, such as medial hypertrophy. Pulmonary vascular Egr-1 expression is significantly increased in patients wit...Continue Reading

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Citations

Jun 3, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Levon M Khachigian
Apr 22, 2016·American Journal of Physiology. Cell Physiology·Justin R SysolRoberto F Machado
Nov 11, 2021·Journal of the American Heart Association·Levon M Khachigian

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