Eicosanoid production and transfer in the placenta of the diabetic pregnancy

Prostaglandins
D C KuhnL M Demers

Abstract

The metabolism of arachidonic acid (AA) and the transfer of its metabolites was determined in in vitro perfused placental tissue from normal pregnancies and those complicated by maternal insulin-dependent diabetes mellitus (IDDM). 14C-labelled AA was recirculated in the fetal circulation for 60 min while 3H-AA was recirculated in the maternal circulation. Placental effluent was subjected to high performance liquid chromatography (HPLC) and analysis of dual-label scintillation counts. Placentae from IDDM pregnancies converted 3-6 times more radiolabelled AA to eicosanoids than did normal placentae. In addition, the transfer of eicosanoids into the opposing circulation was doubled in placentae from IDDM pregnancies compared to normal placentae. The predominant direction of eicosanoid transfer in both groups of placentae was in the fetal-to-maternal direction. The relative amounts of eicosanoids produced was also altered in placentae from IDDM pregnancies. Increased amounts of thromboxane (Tx) B2 and hydroxyeicosatetraenoic acids (HETEs) were present in both circulations of placentae from IDDM pregnancies. Levels of 6-keto prostaglandin F1a (6KPGF1a) were significantly reduced in both circulations in placentae from IDDM pregnancie...Continue Reading

References

Jan 1, 1978·Prostaglandins·M J DuchesneA C de Paulet
Feb 28, 1976·Lancet·M A CrawfordG Williams
Oct 1, 1978·British Journal of Obstetrics and Gynaecology·R L Naeye
Mar 1, 1989·The Journal of Clinical Endocrinology and Metabolism·D M Nelson, S W Walsh
Dec 1, 1989·Prostaglandins·L PatelM G Elder
Dec 1, 1989·American Journal of Obstetrics and Gynecology·D M Nelson, E M Curran
Dec 1, 1988·American Journal of Obstetrics and Gynecology·J A ThorpP C Brath
Oct 1, 1986·American Journal of Obstetrics and Gynecology·E PinterF Naftolin
Nov 1, 1986·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U Ekblad
Jan 1, 1986·Prostaglandins, Leukotrienes, and Medicine·D G GlanceL Myatt
Feb 1, 1985·American Journal of Obstetrics and Gynecology·D G GlanceL Myatt
Apr 15, 1984·American Journal of Obstetrics and Gynecology·M BusaccaE Dejana
Apr 1, 1982·Prostaglandins, Leukotrienes, and Medicine·M D MitchellD M Strickland

❮ Previous
Next ❯

Citations

Sep 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P SaldeenS al-Sedairy
Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Thomas WelssKlaus R Schröder
Jan 24, 1998·Prostaglandins·W R SchaeferH P Zahradnik
Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Pia SaldeenRicardo N Laurini
Jan 15, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E GonzálezM Gimeno
May 1, 1993·American Journal of Obstetrics and Gynecology·R FigueroaM S Wolin
Dec 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R M van der WeidenM J Keirse
Sep 10, 2015·Hormone Molecular Biology and Clinical Investigation·Emilio Herrera, Gernot Desoye
Jan 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D L BooneP C Leung
Oct 27, 2005·The Journal of Clinical Endocrinology and Metabolism·Ali VarastehpourSylvie Hauguel-de Mouzon
Dec 23, 2020·International Journal of Molecular Sciences·Małgorzata SzczukoMaciej Ziętek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.