Eicosanoid production by uterine strips and by embryos obtained from diabetic pregnant rats

A JawerbaumM Gimeno


Eicosanoid production by uterine strips and by embryos obtained from normal and diabetic rats at day 10 of pregnancy was studied. It was found that the release of 6-keto-PGF1 alpha (representing PGI2 synthesis) and of LTB4 was less in preparations from diabetic animals than in controls. The production of TXB2 (indicating the formation of TXA2) by uterine tissue obtained from diabetic rats was almost double that of controls. The synthesis and release of eicosanoids when tissues were incubated in glucose-containing solution or in glucose-free medium were similar, with the exception of LTB4, which was diminished with uterine strips from diabetic rats. The mean number of embryos in control pregnant rats (12.4 +/- 0.5) and in diabetic mothers (10.1 +/- 1.3) was not significantly different, but in 4 of the 14 diabetic rats studied, all of their embryos were resorbed. Although embryos released large amounts of PGF2 and PGE2, and small amounts of 6-keto-PGF1 alpha, TXB2 and LTB4, the amounts of each eicosanoid in control and diabetic groups were similar. The present results indicate that the diabetic state, which induces alterations in uterine eicosanoid production, do not influence arachidonic metabolism in their corresponding embryos.


Jun 1, 1979·European Journal of Clinical Investigation·V A ZibohW Lucky
Jan 1, 1986·The Diabetes Educator·M P DiamondW K Vaughn
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D G PayanE J Goetzl
Jun 1, 1983·Prostaglandins, Leukotrienes, and Medicine·A L GimenoM F Gimeno
Sep 1, 1980·Journal of Reproduction and Fertility·N L Poyser, F M Scott
Apr 1, 1981·The Journal of Experimental Zoology·K L KleinJ G Wilson
Nov 1, 1963·Diabetes·J M MARTINR G EVENS

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Jul 1, 1995·Prostaglandins·A JawerbaumM A de Gimeno
Jan 15, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E GonzálezM Gimeno
Nov 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A JawerbaumM A Gimeno
Dec 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J Roselló-CatafauE Gelpí
Apr 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E T GonzálezM A Gimeno
Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Ricardo A L DE SousaJulia R Clarke
Oct 3, 2013·American Journal of Physiology. Endocrinology and Metabolism·Raymond C Pasek, Maureen Gannon
Jun 11, 2010·Endocrine Reviews·Alicia Jawerbaum, Verónica White
Jul 19, 2020·International Journal of Molecular Sciences·Emilyn U AlejandroMaria Ruth B Pineda-Cortel
Mar 9, 2000·Diabetes/metabolism Research and Reviews·J J Gagliardino
Feb 16, 2021·American Journal of Physiology. Endocrinology and Metabolism·Hefei WangJian V Zhang

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