PMID: 11919546Mar 29, 2002Paper

Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiology

The Journal of Laboratory and Clinical Medicine
B N Setty, Marie J Stuart

Abstract

Neutrophil activation with the release of intracellular granule contents has been observed in sickle cell disease (SCD). Because leukotriene B(4) (LTB(4)), a 5-lipoxygenase metabolite of arachidonic acid in neutrophils, is a chemoattractant and enhances neutrophil adhesion to endothelium, we assessed plasma levels of this metabolite in controls (n = 9) and individuals with SCD, SS genotype, both in basal "steady state" (n = 37) and during episodes of vaso-occlusion (n = 10) and acute chest syndrome (n = 5). Thirteen patients with SCD, SC genotype, in steady state were also studied. Although no significant differences were noted between the control (136 +/- 32 fmol/mL) and SC genotype (177 +/- 83 fmol/mL, P >.15), LTB(4) levels were markedly increased in patients with SS genotype in basal steady state (207 +/- 64 fmol/mL, P <.003) compared with those in controls. Values were further increased during vaso-occlusion (264 +/- 94 fmol/mL) and acute chest syndrome (363 +/- 124 fmol/mL). These levels were significantly different from measurements taken during steady state (P <.04 and P <.0001, respectively). No correlation was noted between LTB(4) level and total white cell or neutrophil count. Additionally, the significant correlatio...Continue Reading

Citations

Apr 5, 2018·Clinical Hemorheology and Microcirculation·Nicola Conran, John D Belcher
Dec 17, 2009·Hematology·Joshua J Field, Michael R DeBaun
Feb 1, 2009·Expert Review of Hematology·Jessica Knight-PerryJoshua J Field
May 22, 2013·The American Journal of Clinical Nutrition·Undurti N Das
Jan 10, 2018·Pediatric Pulmonology·Aliva DeDeepa Rastogi
Apr 15, 2011·Anemia·Kathryn Blake, John Lima
May 16, 2019·Current Opinion in Pediatrics·Shaina M WillenMichael R DeBaun
Mar 26, 2020·Blood Advances·Joshua J FieldMichael R DeBaun
Aug 21, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Michele Arigliani, Atul Gupta
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caryn S Gonsalves, Vijay K Kalra
May 4, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Paula T MonteiroClaudio Canetti
Jan 26, 2006·American Journal of Physiology. Endocrinology and Metabolism·Marvin ReidFarook Jahoor
Dec 23, 2015·The Journal of Clinical Investigation·Marthe-Sandrine Eiymo Mwa MpolloPunam Malik
Jun 13, 2019·Prostaglandins, Leukotrienes, and Essential Fatty Acids·B N Yamaja SettyMarie J Stuart
Aug 22, 2017·Blood Reviews·Vijay K KalraStanley M Tahara
Apr 13, 2021·Biomedical Chromatography : BMC·Yunxia YuanLongshan Zhao
Jun 1, 2021·British Journal of Pain·Kensuke TakaokaRajan Radhakrishnan
Jul 2, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Thassila N PitangaMarilda S Goncalves

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.