Eicosanoids in the gastrointestinal tract

British Journal of Pharmacology
John L Wallace

Abstract

Eicosanoids play important roles in modulating inflammation throughout the body. The gastrointestinal (GI) tract, in part because of its intimate relationship with the gut microbiota, is in a constant state of low-grade inflammation. Eicosanoids like PGs, lipoxins and leukotrienes play essential roles in maintenance of mucosal integrity. On the other hand, in some circumstances, these mediators can become major drivers of inflammatory processes when the lining of the GI tract is breached. Drugs such as nonsteroidal anti-inflammatories, by altering the production of various eicosanoids, can dramatically impact the ability of the GI tract to respond appropriately to injury. Disorders such as inflammatory bowel disease appear to be driven in part by altered production of eicosanoids. Several classes of drugs have been developed that target eicosanoids. LINKED ARTICLES: This article is part of a themed section on Eicosanoids 35 years from the 1982 Nobel: where are we now? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.8/issuetoc.

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Citations

Oct 3, 2018·British Journal of Pharmacology·Khaled ElmasryMohamed Al-Shabrawey
Apr 7, 2019·British Journal of Pharmacology·Roderick J Flower
Apr 20, 2020·Molecular Nutrition & Food Research·Juan Antonio Giménez-BastidaClaus Schneider
Mar 29, 2020·Frontiers in Nutrition·Liliana C BaptistaThomas W Buford
Sep 27, 2019·Frontiers in Microbiology·Eder Soares PiresLuis Caetano Martha Antunes
Jan 1, 2021·Plants·Maria Graça MiguelAna Cristina Figueiredo
Feb 20, 2021·Frontiers in Immunology·Abigail R BassonAlex Rodriguez-Palacios
Mar 16, 2021·Journal of Biomolecular Structure & Dynamics·Prasanth GhantaBasavaraju Ramaiah
May 30, 2021·Prostaglandins & Other Lipid Mediators·Ghassan MustafaKay D Beharry

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