PMID: 12769916Feb 21, 1997Paper

Eicosanoids mediate microaggregation and nodulation responses to bacterial infections in black cutworms, Agrotis ipsilon, and true armyworms, Pseudaletia unipuncta

Journal of Insect Physiology
D Stanley-SamuelsonR A. Jurenka

Abstract

Nodulation is the first, and quantitatively predominant, cellular defense reaction to bacterial infection in insects and other invertebrates. Inhibition of eicosanoid biosynthesis in true armyworms, Pseudaletia unipuncta, and black cutworms, Agrotis ipsilon, immediately prior to intrahemocoelic injections with heat-killed preparations of the bacterium, Serratia marcescens, severely impaired the nodulation response. Five eicosanoid biosynthesis inhibitors, including dexamethasone (a phospholipase A(2) inhibitor), indomethacin, ibuprofen (cyclooxygenase inhibitors), phenidone (dual lipoxygenase/cyclooxygenase inhibitor) and eicosatetraynoic acid (an arachidonic acid analog that inhibits all arachidonic acid metabolism) severely reduced nodulation in infected insects. The dexamethasone effects were reversed by treating true armyworms with arachidonic acid immediately after infection. In addition to these pharmacological findings, we demonstrate that an eicosanoid biosynthesis system is present in these insects. Arachidonic acid is present in fat body phospholipids at about 0.4% of total phospholipid fatty acids. Fat body expressed a phospholipase A(2) that can hydrolyze arachidonic acid from the sn-2 position of cellular phospholi...Continue Reading

References

Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D W Stanley-SamuelsonR W Howard
Mar 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·J M Uscian, D W Stanley-Samuelson
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·J S MillerD W Stanley-Samuelson
Jan 1, 1994·Archives of Insect Biochemistry and Physiology·D Baines, R G Downer
Jan 1, 1993·Archives of Insect Biochemistry and Physiology·J M Uscian, D W Stanley-Samuelson
May 1, 1994·Insect Biochemistry and Molecular Biology·D W Stanley-Samuelson, C L Ogg
Oct 1, 1995·Insect Biochemistry and Molecular Biology·V K PedibhotlaD W Stanley-Samuelson
Jan 1, 1994·Parasitology Today·S CociancichJ A Hoffmann

❮ Previous
Next ❯

Citations

Jul 28, 1999·Archives of Insect Biochemistry and Physiology·R A JurenkaD W Stanley
Jan 30, 2002·Archives of Insect Biochemistry and Physiology·Hasan TunazDavid W Stanley
Mar 29, 2002·Archives of Insect Biochemistry and Physiology·Elizabeth WillottHung Q Tran
Sep 5, 2002·Archives of Insect Biochemistry and Physiology·Jeffrey C LordDavid W Stanley
May 29, 2003·Journal of Insect Physiology·D W. StanleyR W. Howard
Oct 26, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·D W StanleyJ S Miller
Feb 27, 2001·Insect Biochemistry and Molecular Biology·H TunazD W Stanley
Sep 27, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Pamela K PhelpsDavid W Stanley
Sep 7, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J C BedickD W Stanley
Dec 8, 2005·Annual Review of Entomology·David Stanley
Feb 25, 2014·Toxicon : Official Journal of the International Society on Toxinology·M S DefferrariC R Carlini
Mar 26, 2003·Archives of Insect Biochemistry and Physiology·S BundeyA K Charnley
Apr 12, 2005·Archives of Insect Biochemistry and Physiology·Vanessa FranssensJozef Vanden Broeck
Apr 12, 2005·Archives of Insect Biochemistry and Physiology·Jon S Miller
Oct 20, 2005·Archives of Insect Biochemistry and Physiology·Youngjin ParkDavid Stanley
Apr 17, 2008·Archives of Insect Biochemistry and Physiology·F L García Gil de MuñozF C Hernández-Hernández
Apr 8, 2014·Cellular Signalling·Valluri V SatyavathiJavaregowda Nagaraju
Dec 19, 2002·Archives of Insect Biochemistry and Physiology·Hasan TunazDavid W Stanley

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.