Eicosapentaenoic acid monoglyceride resolves inflammation in an ex vivo model of human peripheral blood mononuclear cell

European Journal of Pharmacology
Caroline MorinSamuel Fortin

Abstract

Phosphorylation and activation of p38 MAPK and NFκB pathways, along with the resulting overproduction of interleukin IL-1β, IL-6, and tumor necrosis factor a (TNFα) is a hallmark of inflammatory disorders. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementations are known to exert anti-inflammatory properties by reduction of keys cytokines and enzymes involved in inflammation. Here, we investigated the anti-inflammatory pathways and mediators modulated by eicosapentaenoic acid monoglyceride (MAG-EPA) on human peripheral blood mononuclear cells (PBMCs) from healthy donors and stimulated, ex vivo, with lipopolysaccharide (LPS). LPS stimulation increased p38 MAPK and NFκB phosphorylation, which was abolished by MAG-EPA treatments. Concomitantly, MAG-EPA also abolished LPS-induced inflammation in PBMCs by reducing IL-1β, IL-6, and TNFα cytokines at protein and transcript levels. Moreover, MAG-EPA decreased the levels of HIF1α in LPS-induced human PBMCs. Results also revealed a decreased of pro-inflammatory enzymes such as Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) in LPS-induced PBMCs. Altogether, the present data suggest that MAG-EPA, represents a new potential therapeutic strategy for resolving inflammation in infl...Continue Reading

Citations

Mar 8, 2018·Nutrients·Bill TachtsisOrly Lacham-Kaplan
Oct 1, 2020·Nutrients·Il-Young JangBeom-Jun Kim
Jun 27, 2018·BMC Pregnancy and Childbirth·Ellen L MozurkewichZora Djuric
Dec 25, 2019·Oxidative Medicine and Cellular Longevity·Qian-Yi SunXiao-Yuan Mao
Nov 15, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Anan YaghmurStefan Salentinig

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