Eicosapentaenoic acid prevents memory impairment after ischemia by inhibiting inflammatory response and oxidative damage

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Naohiko OkabeT Itano

Abstract

Previous studies have demonstrated that the generation of reactive oxygen species and an excessive inflammatory reaction are involved in the progression of neural damage following brain ischemia. In this study, we focused on the anti-inflammatory and antioxidant properties of eicosapentaenoic acid (EPA). Gerbils were treated intraperitoneally with 500 mg/kg of EPA ethyl for 4 weeks until the day of forebrain ischemia, which was induced by occluding the bilateral common carotid artery for 5 minutes. In the first part of the 2-part experiment, the effect of EPA treatment was evaluated using hematoxylin and eosin staining and deoxynucleotidyl transferase-mediated dUTP nick-end labeling as a marker of cell death (n=3 per group). The inflammatory reaction was evaluated using anti-Iba1 immunohistochemistry, a marker of microglial activation (n=3 per group), and detection of 8-hydroxyl-2'-deoxyguanosine, a marker of oxidative DNA damage (n=4 per group). In the second part of the experiment, the effect of EPA treatment on memory function was examined using an 8-arm radial maze (n=6 per group). EPA treatment significantly inhibited DNA oxidative damage (P < .05) and accumulation of Iba1-positive cells in the CA1 area at 12 and 72 hours ...Continue Reading

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Citations

Aug 25, 2012·Pulmonary Medicine·Joshua LawrenzRichard C Baybutt
Dec 3, 2014·Brain Research Bulletin·Yanan LiuToshifumi Itano
Jun 27, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hongjian PuYanqin Gao
Nov 29, 2013·Human Psychopharmacology·Isabelle BauerDavid Crewther
Jun 19, 2013·Physiology & Behavior·Cristiano Correia BacarinHumberto Milani
Jun 4, 2015·European Journal of Pharmacology·Marc-Olivier TrépanierRichard P Bazinet
Oct 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung-Yup LeeChi-Un Pae
Jun 18, 2016·Journal of Nutrition and Metabolism·Maria Elizabeth Pereira NobreGlauce Socorro de Barros Viana
Jan 31, 2017·International Journal of Molecular Sciences·Olatz ArteagaEnrique Hilario
Mar 26, 2019·Annual Review of Food Science and Technology·Rebecca PowerJohn M Nolan
Dec 13, 2017·Cardiovascular Psychiatry and Neurology·Graham MazereeuwKrista L Lanctôt
Jan 30, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Zhijuan MiaoYuwu Zhao

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