Eicosapentaenoic acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity-independent manner

The Journal of Nutrition
Monique J LeMieuxNaima Moustaid-Moussa

Abstract

Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, inflammation, and thrombosis. Research to develop nutritional interventions to prevent or treat obesity and its associated diseases is greatly needed. Previously, we demonstrated the ability of eicosapentaenoic acid (EPA) to prevent high-fat (HF) diet-induced obesity, insulin resistance, and inflammation in mice. The objective of the current study was to determine the mechanisms mediating the anti-inflammatory and antilipogenic actions of EPA. In a previous study, male C57BL/6J mice were fed a low-fat diet (10% of energy from fat), an HF diet (45% of energy from fat), or an HF diet supplemented with EPA (45% of energy from fat; 36 g/kg EPA; HF+EPA) for 11 wk or an HF diet for 6 wk and then switched to the HF+EPA diet for 5 wk. In this study, we used histology/immunohistochemistry, gene expression, and metabolomic analyses of white adipose tissue from these mice. In addition, cultured mouse 3T3-L1 adipocytes were treated with 100 μM EPA for 48 h and then used for extracellular flux assays with untreated 3T3-L1 adipocytes used as a control. Compared with the HF diet, the HF+EPA diet significantly reduced body weight, a...Continue Reading

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Citations

Apr 26, 2015·Seminars in Immunology·Sarah E Headland, Lucy V Norling
Nov 12, 2016·The Journal of Nutritional Biochemistry·Mandana PahlavaniNaima Moustaid-Moussa
Oct 27, 2017·Nutrients·Priscila Silva FigueiredoPriscila Aiko Hiane
Nov 28, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Aline Haas de MelloGislaine Tezza Rezin
Aug 29, 2020·The Journal of Pharmacy and Pharmacology·Thamires Barros TavaresCristiane Aguiar da Costa
Jun 17, 2020·Annual Review of Nutrition·Nishan Sudheera KalupahanaNaima Moustaid-Moussa
Mar 27, 2018·Journal of Mammary Gland Biology and Neoplasia·Saraswoti KhadgeJames E Talmadge
Jul 3, 2018·Journal of Nutritional Science and Vitaminology·Rosa María Oliart RosAlfonso Alexander-Aguilera
Dec 15, 2015·Current Opinion in Lipidology·Soonkyu Chung, John S Parks
Nov 23, 2017·The Journal of Biological Chemistry·E Madison SullivanSaame Raza Shaikh
Aug 2, 2017·Metabolic Brain Disease·Aline Marcelino de AndradeRenata Padilha Guedes
Aug 6, 2020·International Journal of Molecular Sciences·Veronica D DahikWilfried Le Goff
Jul 14, 2020·Adipocyte·Mohammad YosofvandHanna Moussa
Oct 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paola IllescaLuis A Videla
Oct 1, 2020·Biomolecules·Iurii KobozievNaima Moustaid-Moussa
Feb 13, 2021·International Journal of Molecular Sciences·Francesca ParisiIrene Cetin
Mar 4, 2021·Nutrients·Roberta Dourado Cavalcante da Cunha de SáMaria Isabel Alonso-Vale
Jul 17, 2021·The Journal of Nutritional Biochemistry·Emily K MillerNaima Moustaid-Moussa

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