Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts

Journal of Cardiovascular Pharmacology
Hisakazu OgitaMasafumi Kitakaze

Abstract

Intake of fish oil is known to have cardioprotective effects and reduce cardiovascular mortality. However, it is not widely recognized that eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids (PUFAs), exerts beneficial effects against myocardial ischemia/reperfusion injury. The purpose of this study is to investigate whether EPA attenuates the severity of myocardial ischemia/reperfusion injury and which cellular mechanism is involved. Rabbits were treated with or without EPA (600 mg/kg/day) for 2 weeks. Infarct size was measured in open-chest rabbits after 30-minute occlusion of the left anterior descending coronary artery (LAD) and after the subsequent 3-hour reperfusion. In several groups, NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthase, or charybdotoxin, a blocker of calcium-activated potassium (K(Ca)) channels, was infused intravenously beginning 20 minutes before LAD occlusion and continuing during reperfusion. Infarct size was reduced in the group treated with EPA compared with the control group (7.2 +/- 1.0% vs 24.6 +/- 2.3%; P < 0.01). The occurrence of ventricular arrhythmias in the reperfusion period tended to decrease in the EPA group. Either L-NAME or charybd...Continue Reading

References

Mar 1, 1987·Basic Research in Cardiology·A Yanagisawa, A M Lefer
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·S PepeE Lakatta
Jun 15, 1995·Biochemical and Biophysical Research Communications·K NodeT Kamada
Apr 13, 1995·The New England Journal of Medicine·A AscherioW C Willett
Sep 1, 1993·British Heart Journal·S D KristensenS Endres
Apr 1, 1993·Journal of the American College of Cardiology·H J OskarssonJ X Thomas
Jan 1, 1996·The Journal of Nutrition·S Pepe, P L McLennan
Apr 10, 1997·The New England Journal of Medicine·M L DaviglusR B Shekelle
Mar 17, 1997·Biochemical and Biophysical Research Communications·Y OkudaK Yamashita
Jan 10, 1998·JAMA : the Journal of the American Medical Association·C M AlbertJ E Manson
Jan 5, 2000·The American Journal of Clinical Nutrition·D S SiscovickR H Knopp
Jul 20, 2000·Clinical and Experimental Pharmacology & Physiology·M NishimuraM Yoshimura
Aug 18, 2000·The Journal of Surgical Research·S SaneT Aikou
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Y ZhangM VanRollins
Oct 19, 2001·Basic Research in Cardiology·H AsanumaM Hori

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Citations

Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sekar Ashok KumarPalaninathan Varalakshmi
Sep 12, 2013·The Proceedings of the Nutrition Society·Cherry L Wainwright, Lisa Michel
Nov 26, 2009·European Heart Journal·Satoshi Yasuda, Hiroaki Shimokawa
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Sanjay MisraDebabrata Mukhopadhyay
May 19, 2007·The Journal of Physiology·Norbert SzentandrássyStephen C O'Neill
Jun 10, 2011·Journal of Molecular and Cellular Cardiology·Ryuji TsuburayaHiroaki Shimokawa
Sep 8, 2017·Experimental Physiology·Alcione Lescano de Souza JuniorRui Curi
May 29, 2018·Canadian Journal of Physiology and Pharmacology·Mélissa DesnoyersGuy Rousseau
Mar 11, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yong-Fu XiaoPaul A Iaizzo
Oct 16, 2014·Food & Function·Marcela A MartinsAntônio Cláudio Mendes-Ribeiro
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kazuhisa KitamuraToyoaki Murohara
Jun 2, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Jun Yi GaoHiroaki Shimokawa

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