Eicosenoid biosynthesis and platelet function with advancing age

Thrombosis Research
I A Reilly, G A FitzGerald

Abstract

The pathogenesis of atherosclerosis, a major cause of age-related mortality, remains poorly understood. Although platelets and their products, including thromboxane A2, may be of importance in this process, little is known about eicosenoid biosynthesis and platelet function with increasing age. In order to address the hypothesis that platelet activation increases with age, we measured various indices of platelet function in a group of apparently healthy individuals over the age of 50 years. The circulating platelet aggregate ratio, plasma beta-thromboglobulin and threshold aggregating concentration of arachidonic acid were similar to those in healthy subjects aged less than 40 years. Although the bleeding time (168 +/- 24 vs 300 +/- 24 seconds) was significantly (p less than 0.001) shorter in the older volunteers this may be unrelated to platelet function and merely reflect age related changes in skin and/or vascular function. To further assess platelet and vascular function in vivo, we measured excretion of the major thromboxane and prostacyclin metabolites in urine, 2,3-donor-thromboxane B2 (Tx-M) and 2,3-dinor-6-keto-PGF1 alpha (PGI-M). Both Tx-M (223 +/- 22 vs 152 +/- 19 pg/mg creatinine; p less than 0.005) and PGI-M (198 +...Continue Reading

References

Jun 29, 1978·Nature·S MoncadaJ R Vane
Jul 1, 1979·Progress in Cardiovascular Diseases·A I Schafer, R I Handin
Sep 1, 1978·Microvascular Research·S BernickR G Lindal
Aug 19, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Jan 31, 1975·Nature·M JohnsonP W Ramwell
Nov 1, 1982·Archives of Neurology·M FisherD A Drachman
Apr 26, 1984·The New England Journal of Medicine·G A FitzGeraldA R Brash
Feb 1, 1980·Thrombosis Research·J ZahaviV V Kakkar
Nov 1, 1982·Prostaglandins, Leukotrienes, and Medicine·O YlikorkalaL Viinikka
Nov 1, 1981·The Journal of Clinical Investigation·G A FitzGeraldJ A Oates
Apr 1, 1982·Prostaglandins·I A BlairC T Dollery
Sep 15, 1980·Thrombosis Research·K A JørgensenE Stoffersen

❮ Previous
Next ❯

Citations

Jan 1, 1993·International Journal of Clinical & Laboratory Research·R AbbateG F Gensini
Mar 1, 1992·Aging : Clinical and Experimental Research·A NotarbartoloG Davì
Oct 2, 2007·Journal of Thrombosis and Thrombolysis·Richard C Becker
Oct 1, 1993·Mechanisms of Ageing and Development·D KasjanovováL Hegyi
Mar 1, 1988·Thrombosis Research·P A Frith, C P Warlow
Jul 1, 1989·Baillière's Clinical Haematology·J Vermylen, D Blockmans
Jul 1, 1989·Clinical and Experimental Pharmacology & Physiology·M J SturmR R Taylor
Jan 1, 1989·Journal of Internal Medicine. Supplement·M LagardeC Calzada
Jul 17, 2015·Scientific Reports·Jonathan CowmanDermot Kenny
Mar 1, 1987·Journal of the American Geriatrics Society·M MenconiP Polgar
Jul 25, 2006·Critical Reviews in Oncology/hematology·Massimo Franchini
Aug 25, 2015·Mechanisms of Ageing and Development·Cesar SepúlvedaEduardo Fuentes
Apr 14, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Chris I Jones
Feb 12, 2014·Journal of the American Geriatrics Society·Donya MohebaliMatthew T Rondina
May 15, 2007·Journal of the American College of Cardiology·Francesco MartinoFrancesco Violi
Sep 27, 2016·Thrombosis Research·Magdalena L BochenekKatrin Schäfer
Aug 18, 2017·Antioxidants & Redox Signaling·Francesco VioliDaniele Pastori
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·C J KnightA H Goodall
Jun 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J D EmeryJ B Lawrence
Jul 28, 1988·The New England Journal of Medicine·P AlessandriniG A FitzGerald
Sep 2, 2020·Cancer Metastasis Reviews·Alessandra V S FariaGwenny M Fuhler
Aug 3, 2020·Current Opinion in Hematology·Orlando EsparzaPavel Davizon-Castillo
May 10, 2020·International Journal of Molecular Sciences·Whitney VenturiniRodrigo Moore-Carrasco
Aug 27, 2019·Frontiers in Cardiovascular Medicine·Jessica Le Blanc, Marie Lordkipanidzé
May 1, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P RossiA Riutta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved