eIF3: a factor for human health and disease

RNA Biology
Andreia Gomes-DuarteLuísa Romão

Abstract

The eukaryotic initiation factor 3 (eIF3) is one of the most complex translation initiation factors in mammalian cells, consisting of several subunits (eIF3a to eIF3m). It is crucial in translation initiation and termination, and in ribosomal recycling. Accordingly, deregulated eIF3 expression is associated with different pathological conditions, including cancer. In this manuscript, we discuss the interactome and function of each subunit of the human eIF3 complex. Furthermore, we review how altered levels of eIF3 subunits correlate with neurodegenerative disorders and cancer onset and development; in addition, we evaluate how such misregulation may also trigger infection cascades. A deep understanding of the molecular mechanisms underlying eIF3 role in human disease is essential to develop new eIF3-targeted therapeutic approaches and thus, overcome such conditions.

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Citations

Sep 26, 2020·Dose-response : a Publication of International Hormesis Society·Heng JiaoWenhui Lou
Sep 22, 2020·Wiley Interdisciplinary Reviews. RNA·Geena Skariah, Peter K Todd
Nov 6, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Giovanna Maldonado, Greco Hernández
Jan 15, 2021·Journal of Cell Science·Rachael C L SmithOwen J Sansom
Jan 28, 2021·International Journal of Molecular Sciences·Ying Li, David Reverter
Jan 9, 2021·Cell Death & Disease·Hongsheng LiuYingyi Wang

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Methods Mentioned

BETA
GTPases
ubiquitination

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