Eight genes are highly associated with BMD variation in postmenopausal Caucasian women

Bone
Sjur ReppeKaare M Gautvik

Abstract

Low bone mineral density (BMD) is an important risk factor for skeletal fractures which occur in about 40% of women >/=50 years in the western world. We describe the transcriptional changes in 84 trans-iliacal bone biopsies associated with BMD variations in postmenopausal females (50 to 86 years), aiming to identify genetic determinants of bone structure. The women were healthy or having a primary osteopenic or osteoporotic status with or without low energy fractures. The total cohort of 91 unrelated women representing a wide range of BMDs, were consecutively registered and submitted to global gene Affymetrix microarray expression analysis or histomorphometry. Among almost 23,000 expressed transcripts, a set represented by ACSL3 (acyl-CoA synthetase long-chain family member 3), NIPSNAP3B (nipsnap homolog 3B), DLEU2 (Deleted in lymphocytic leukemia, 2), C1ORF61 (Chromosome 1 open reading frame 61), DKK1 (Dickkopf homolog 1), SOST (Sclerostin), ABCA8, (ATP-binding cassette, sub-family A, member 8), and uncharacterized (AFFX-M27830-M-at), was significantly correlated to total hip BMD (5% false discovery rate) explaining 62% of the BMD variation expressed as T-score, 53% when adjusting for the influence of age (Z-score) and 44% whe...Continue Reading

References

Apr 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B EttingerH K Genant
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T W O'NeillA J Silman
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P LipsI Wiklund
Aug 18, 1997·The American Journal of Medicine·C Cooper
Nov 14, 1997·American Journal of Public Health·J MagazinerJ R Hebel
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tetsuyuki HayashibaraToshiyuki Yoneda
May 24, 2005·The Journal of Biological Chemistry·Mikhail SemënovXi He
Jun 20, 2006·Current Topics in Developmental Biology·Donald A Glass, Gerard Karsenty
Sep 26, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yong-Jun LiuHong-Wen Deng
Jan 18, 2007·American Journal of Physiology. Endocrinology and Metabolism·Sjur ReppeKaare M Gautvik
May 25, 2007·Current Osteoporosis Reports·Giolanta Kogianni, Brendon S Noble
Jul 7, 2007·Bone·Bryan T MacDonaldPeter V Hauschka
Aug 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Olivier LeupinHansjoerg Keller
Nov 2, 2007·Journal of Neurochemistry·Woojin Scott KimBrett Garner
Nov 21, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anne-Marie SimsMatthew A Brown
Apr 25, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peng XiaoHong-Wen Deng
May 1, 2008·The New England Journal of Medicine·Unnur StyrkarsdottirKari Stefansson
May 1, 2008·The New England Journal of Medicine·Joel N Hirschhorn, Luigi Gennari
May 29, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gunnar SigurdssonKari Stefansson
Aug 9, 2008·Blood·Joseph J PinzoneJohn D Shaughnessy
Aug 19, 2008·Cancer Biology & Therapy·Elaine Y ChungAndrei Thomas-Tikhonenko
Dec 17, 2008·Nature Genetics·Unnur StyrkarsdottirKari Stefansson
Feb 24, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Bernadett BallaPéter Lakatos
Apr 30, 2009·Blood·Aldo M RoccaroIrene M Ghobrial

❮ Previous
Next ❯

Citations

Jan 3, 2012·Current Osteoporosis Reports·Wei Zhang, Matthew T Drake
Dec 12, 2012·Omics : a Journal of Integrative Biology·Karen Rojo VenegasMiguel Angel Calleja Hernández
May 27, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel CejkaMartin Haas
Jun 5, 2013·Genome Medicine·Shuyan WuHong-Wen Deng
May 6, 2011·The Journal of Clinical Endocrinology and Metabolism·Melissa McNultyRajiv Kumar
Dec 18, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Daniel CejkaHartmut H Malluche
Sep 8, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Athanasios D AnastasilakisKonstantinos A Toulis
Sep 4, 2015·Molecular Medicine Reports·Yanqing LiuLili Xu
Sep 25, 2015·Calcified Tissue International·Melissa M Formosa, Angela Xuereb-Anastasi
Apr 1, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rune JemtlandKaare M Gautvik
Aug 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wesley G BeamerLeah Rae Donahue
Mar 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mattia CapulliAnna Teti
Aug 27, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sjur ReppeKaare M Gautvik
Jan 11, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yuan-Cheng ChenHong-Wen Deng
Sep 4, 2016·BMC Bioinformatics·Kukatharmini TharmaratnamArnoldo Frigessi
Dec 6, 2016·Journal of Cellular Biochemistry·Hong-Xing ZhaoJin-Gang Tao
Dec 1, 2017·International Journal of Molecular Sciences·Irma KarabegovićMohsen Ghanbari
Jan 8, 2014·Hypertension·Ole A AndreassenUNKNOWN International Consortium for Blood Pressure Genome-Wide Association Studies, Genetic Factors for Osteoporosis Consortium
Sep 27, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hai-Ming HuWenhua Li
Aug 28, 2020·Statistics in Medicine·Solveig Engebretsen, Ingrid K Glad
Jun 27, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Sjur ReppeKaare M Gautvik
Mar 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yi-Hsiang HsuDavid Karasik
Oct 12, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W ZhuH-W Deng
May 28, 2019·Frontiers in Endocrinology·Robert D Maynard, Cheryl L Ackert-Bicknell
Aug 2, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Carrie M NielsonYi-Hsiang Hsu
Mar 25, 2019·Experimental and Therapeutic Medicine·Ya-Peng ZhangHui Leng
Feb 6, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kaare M GautvikSjur Reppe
Jun 17, 2020·Therapeutic Advances in Musculoskeletal Disease·Ole Kristoffer OlstadKaare Morten Gautvik
Jan 27, 2019·Experimental and Therapeutic Medicine·Honghai CaoPeifu Tang
Sep 12, 2020·Bioinformatics·Chubing ZengJuan Pablo Lewinger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved