Eight genotypes (A-H) of hepatitis B virus infecting patients from San Francisco and their demographic, clinical, and virological characteristics

Journal of Medical Virology
Hideaki KatoM Mizokami

Abstract

Clinical lines of evidence have been accumulated that hepatitis B virus (HBV) genotypes have characteristic geographical distributions and distinct clinical impact on liver diseases. The distribution of HBV genotypes was determined with reference to hepatitis B e antigen (HBeAg) and alanine aminotransferase (ALT) levels in 165 patients with hepatitis B in San Francisco. HBV genotypes were determined by enzyme-linked immunosorbent assay (ELISA) and the unclassified samples were sequenced within the S region for phylogenetic analysis. Genotype A occurred in 60 (36%) patients, B in 16 (10%), C in 56 (34%), D in 19 (12%), E in 1 (1%), F in 1 (1%), G in 8 (5%), and H in 4 (2%). Caucasians were infected predominantly with HBV genotype A (HBV/A) (38 of 57 [67%]), Asians with HBV/C (45 of 63 [71%]), and Hispanics with HBV/F and HBV/H (4 of 9 [44%]). Serum ALT levels were higher in the patients infected with HBV/A (P = 0.03) or HBV/G (P = 0.02) than HBV/C. HBeAg was more frequent in patients infected with HBV/G than HBV/C or HBV/D (7 of 8 [88%] vs. 25 of 56 [45%] or 6 of 19 [32%], P = 0.03 or 0.01). In conclusion, eight genotypes (A-H) were identified in San Francisco in association with various ethnicities and then influenced ALT level...Continue Reading

References

Dec 11, 1997·The New England Journal of Medicine·W M Lee
Jan 21, 2000·The Journal of General Virology·L StuyverR Rossau
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E OritoS Iino
Mar 20, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A M BozdayiO Uzunalimoğlu
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hideaki KatoMasashi Mizokami
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen Chu, Anna S F Lok
Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Sep 5, 2002·Journal of Medical Virology·L V SánchezA Panduro
Aug 2, 2003·Gastroenterology·Chi-Jen ChuAnna S F Lok
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chi-Jen ChuUNKNOWN U.S. HBV Epidemiology Study Group
Dec 23, 2003·Intervirology·Yuzo Miyakawa, Masashi Mizokami
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

❮ Previous
Next ❯

Citations

May 18, 2006·Journal of Gastroenterology and Hepatology·Yi-Wen HuangDing-Shinn Chen
Sep 7, 2006·Journal of Clinical Microbiology·Tania M WelzelBetty A Ortiz-Conde
Sep 12, 2013·World Journal of Gastroenterology : WJG·Sonia Roman, Arturo Panduro
Oct 25, 2014·Genome Announcements·Sergio HernándezRodrigo A Villanueva
Jun 2, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Andres F CarrionPaul Martin
Oct 17, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Judith M HübschenClaude P Muller
Dec 2, 2015·Archives of Virology·Sergio HernándezRodrigo A Villanueva
Feb 7, 2007·Virus Research·Marisol Devesa, Flor H Pujol
May 29, 2009·Journal of Medical Virology·Ana MotaMargarida Fonseca Cardoso
Jul 14, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Anna Kramvis, Michael C Kew
Aug 30, 2012·Journal of Medical Virology·Suda LouisirirotchanakulBernard Weber
Feb 17, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Fuat KurbanovMasashi Mizokami
Dec 13, 2006·Immunology Letters·Kristelle S BrownTimothy P Hickling
Nov 8, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Magnus Lindh
Nov 15, 2008·The Journal of General Virology·Carla OsiowyJean-Pierre Villeneuve
Oct 23, 2009·The Journal of General Virology·Mónica Viviana Alvarado MoraJoão Renato Rebello Pinho
Aug 21, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ruxandra CalinVincent Thibault
Oct 29, 2014·International Journal of Hepatology·Kojiro MichitakaYoichi Hiasa
Jul 23, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Luciana BarbiniRodolfo Campos
Aug 24, 2006·Journal of Medical Virology·Mariko KobayashiHiromitsu Kumada
Jul 11, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Giulia MorsicaUNKNOWN Hepa I.C.o.N.A the Icona Foundation Study Groups
Feb 22, 2005·The Journal of General Virology·Hitoshi OhnumaUNKNOWN JRC NAT Screening Research Group
Oct 31, 2006·World Journal of Gastroenterology : WJG·Cosme Alvarado-EsquivelSergio Aguilar-Benavides
Jan 21, 2006·World Journal of Gastroenterology : WJG·Zhong-Min HuangChun-Lei Lu
Nov 1, 2020·Journal of Viral Hepatitis·Jonas Michel WolfVagner Ricardo Lunge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.