Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough

Pulmonary Pharmacology & Therapeutics
Kian Fan ChungLorcan McGarvey

Abstract

At the Eighth International London Cough Conference held in London in July 2014, the focus was on the relatively novel concept of cough hypersensitivity syndrome (CHS) as forming the basis of chronic cough. This concept has been formulated following understanding of the neuronal pathways for cough and a realisation that not all chronic cough is usually associated with a cause. The CHS is defined by troublesome coughing triggered by low level of thermal, mechanical or chemical exposure. It also encompasses other symptoms or sensations such as laryngeal hypersensitivity, nasal hypersensitivity and possibly also symptoms related to gastrooesopahgeal reflux. The pathophysiologic basis of the CHS is now being increasingly linked to an enhancement of the afferent pathways of the cough reflex both at the peripheral and central levels. Mechanisms involved include the interactions of inflammatory mechanisms with cough sensors in the upper airways and with neuronal pathways of cough, associated with a central component. Tools for assessing CHS in the clinic need to be developed. New drugs may be developed to control CHS. A roadmap is suggested from the inception of the CHS concept towards the development of newer antitussives at the Symp...Continue Reading

References

Aug 13, 1998·Archives of Internal Medicine·C L FrenchC J Krikorian
Aug 15, 2003·American Journal of Respiratory and Critical Care Medicine·Benjamin D M Hope-GillNicholas K Harrison
Sep 28, 2004·American Journal of Respiratory and Critical Care Medicine·David A GronebergK Fan Chung
Jun 22, 2005·Pulmonary Pharmacology & Therapeutics·J PlevkovaM Tatar
Nov 24, 2006·American Journal of Respiratory and Critical Care Medicine·Alyn H MoriceRachel Thompson
Jun 19, 2007·American Journal of Respiratory and Critical Care Medicine·Stuart B MazzoneMichael J Farrell
Aug 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marcello TrevisaniPierangelo Geppetti
Jan 26, 2008·The Journal of Physiology·Christina NassensteinBradley J Undem
Dec 4, 2008·Pulmonary Pharmacology & Therapeutics·L McGarveyR W Costello
Feb 11, 2009·The Laryngoscope·Nicole M Ryan, Peter G Gibson
May 9, 2009·Basic & Clinical Pharmacology & Toxicology·Anne Estrup OlesenAsbjørn Mohr Drewes
Jun 23, 2009·European Journal of Pain : EJP·Christina BrockAsbjørn Mohr Drewes
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Mark A BirrellAlyn H Morice
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stuart B MazzoneBrendan J Canning
Dec 17, 2009·The Journal of Physiology·Thomas E Taylor-Clark, Bradley J Undem
Jan 7, 2010·Chest·Bradley J Undem, Michael J Carr
Jan 22, 2010·Lung·Pierangelo GeppettiSerena Materazzi
Jun 29, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brendan J Canning, Nanako Mori
Feb 5, 2011·Pulmonary Pharmacology & Therapeutics·K F Chung
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stuart B MazzoneMichael J Farrell
May 24, 2011·Respiratory Physiology & Neurobiology·Thomas E Taylor-Clark, Bradley J Undem
Oct 22, 2011·Chest·Jaclyn A SmithBrendan J Canning
Oct 2, 2012·Annual Review of Physiology·Diana M BautistaMakoto Tsunozaki
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Kai K LeeSurinder S Birring
Mar 9, 2013·American Journal of Respiratory and Critical Care Medicine·Helen SumnerJaclyn A Smith
Mar 12, 2013·Pulmonary Pharmacology & Therapeutics·Megan S GraceMaria G Belvisi
Mar 26, 2013·Pulmonary Pharmacology & Therapeutics·D Spina, C P Page
Jun 20, 2013·The Journal of Allergy and Clinical Immunology·Emma C Y HiltonJaclyn A Smith
Oct 8, 2013·American Journal of Respiratory and Critical Care Medicine·Jennifer LeechMichael J Farrell
Jan 7, 2014·Frontiers in Cellular Neuroscience·Anthony P Ford, Bradley J Undem
Jan 17, 2014·The Lancet. Respiratory Medicine·Kian Fan ChungStuart B Mazzone
Mar 29, 2014·Pharmacological Reviews·P V DicpinigaitisC P Page
May 28, 2014·Human Brain Mapping·Michael J FarrellStuart B Mazzone
Aug 22, 2014·The European Respiratory Journal·Alyn H MoriceJaclyn A Smith
Oct 5, 2014·The Journal of Pain : Official Journal of the American Pain Society·Samridhi C GoswamiMichael J Iadarola
Dec 6, 2014·Journal of Applied Physiology·I PoliacekD C Bolser
Dec 20, 2014·The Journal of Pharmacology and Experimental Therapeutics·Peter V DicpinigaitisBlake Paterson

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Citations

Jul 9, 2016·Annals of the New York Academy of Sciences·Craig RothenbergSven-Eric Jordt
Aug 21, 2016·The Medical Clinics of North America·Andreas Achilleos
Aug 18, 2020·Expert Review of Respiratory Medicine·Elzbieta M GrabczakRafal Krenke
May 12, 2017·Experimental Lung Research·Ahmed Z El-Hashim, Sahar M Jaffal
Jun 15, 2019·International Journal of Molecular Sciences·Simona GiorgiSara González-Rodríguez
Mar 30, 2020·MMW Fortschritte der Medizin·Ludger Klimek, Peter Kardos
Oct 8, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Joy Wei-Yan LeeMark Hew

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