Eight new peptaibols from sponge-associated Trichoderma atroviride

Marine Drugs
Irina PanizelShmuel Carmeli

Abstract

Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dimensional NMR measurements. The isolated compounds belong to the trichorzianines, a family of 19-residue linear hydrophobic peptides containing a high proportion of α-aminoisobutyric acid (Aib), an acetylated N-terminus and a C-terminal amino alcohol. These new peptaibols exhibited antimicrobial activity against environmental bacteria isolated from the Mediterranean coast of Israel.

References

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May 18, 2013·Chemistry & Biodiversity·Angélique CarrouxNicolas Ruiz

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Citations

May 27, 2014·Frontiers in Microbiology·Oded Yarden
Jan 27, 2015·Natural Product Reports·John W BluntMichèle R Prinsep
May 21, 2018·Journal of Applied Microbiology·E CastagnoliJ Kurnitski
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mei-Mei ChengGuo-Qiang Li
May 27, 2015·Chemistry & Biodiversity·Nora K N NeumannRainer Schuhmacher
Jun 21, 2018·World Journal of Microbiology & Biotechnology·Ines TouatiFerid Limam
May 22, 2019·Natural Product Reports·Nicholas H OberliesHuzefa A Raja

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Methods Mentioned

BETA
NMR

Software Mentioned

BLAST
Trichokey

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