PMID: 8938713Jan 1, 1996Paper

Eight potassium channel families revealed by the C. elegans genome project

Neuropharmacology
A WeiL Salkoff

Abstract

The wealth of accumulating data from the Caenorhabditis elegans genome sequencing project has rapidly accelerated the discovery of novel potassium channel genes and now places within reach the possibility of describing the total complement of potassium channels used by an individual species. Using annotated GenBank sequences, BLAST searches of unfinished sequences and degenerate oligonucleotide polymerase chain reaction (PCR) screens, we have identified and compiled genes for 38 C. elegans potassium channel and two cyclic nucleotide-gated cation channel subunits, representing eight conserved multigene families. Novel families of potassium channel genes were revealed, as well as conserved homologues of all known vertebrate families. Two separate families represent C. elegans homologues for human potassium channels recently implicated in hereditary long QT arrhythmias. Of particular note is an exceptionally large class of at least 23 genes with a novel subunit structure having two tandem 'P' domains; these channels may form as dimers in contrast to all other potassium channel types which form as tetramers. The 40 potassium channel genes are evenly distributed on all six C. elegans chromosomes, with the exception of the instances ...Continue Reading

References

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B K KaangY Furukawa
May 1, 1992·Trends in Neurosciences·L SalkoffA Wei
Jan 1, 1992·Annual Review of Physiology·L Y Jan, Y N Jan
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A AndersonR F Gaber
Feb 22, 1991·Science·H A HartmannA M Brown
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M D PakL Salkoff
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T ElkinsC F Wu
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W KarpenD A Baylor
Feb 17, 1989·Science·A ButlerL Salkoff
May 1, 1974·Genetics·S Brenner
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Aug 1, 1993·Trends in Pharmacological Sciences·P H Seeburg
Aug 22, 1995·Proceedings. Biological Sciences·E GlowatzkiB Fakler

❮ Previous
Next ❯

Citations

Jun 21, 2006·Journal of Molecular Evolution·Damien M O'HalloranAnn M Burnell
Mar 29, 2008·European Biophysics Journal : EBJ·Alexandra DedmanEric Honoré
Jun 19, 2010·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Abhilash Ponnath, Hamilton E Farris
Apr 20, 2006·Invertebrate Neuroscience : in·Irina VinogradovaLindy Holden-Dye
Jun 2, 2007·Journal of the Association for Research in Otolaryngology : JARO·Irene S GabashviliAnne B S Giersch
Feb 19, 2004·Brain Research. Molecular Brain Research·Dmytro E DuzhyyBernd H A Sokolowski
Dec 5, 2003·Trends in Pharmacological Sciences·Donghee Kim
Feb 11, 1999·Biochemical Pharmacology·C D Bortner, J A Cidlowski
Mar 19, 2002·Brain Research·Carmen GnatencoDonghee Kim
Oct 29, 1998·Toxicon : Official Journal of the International Society on Toxinology·M L GarciaG J Kaczorowski
Aug 26, 2000·Progress in Biophysics and Molecular Biology·B S Brown, S P Yu
Jul 13, 2001·Pharmacology & Therapeutics·J Robbins
Nov 14, 1997·Trends in Pharmacological Sciences·S Grissmer
May 18, 2001·Trends in Neurosciences·A J Patel, E Honoré
Mar 1, 1997·Trends in Neurosciences·J S Trimmer, K J Rhodes
Oct 19, 2000·Brain Research. Molecular Brain Research·F Jow, K Wang
Nov 10, 2000·Brain Research. Molecular Brain Research·F PanofenG Jeserich
Feb 13, 2001·Brain Research. Molecular Brain Research·A D MedhurstM N Pangalos
Apr 13, 2001·Neuroscience·L SalkoffA Wei
Jul 8, 1999·Current Opinion in Neurobiology·G Yellen
Dec 29, 1998·Molecular Medicine Today·J J GargusG A Gutman
Jan 6, 1999·The European Journal of Neuroscience·J Kupper
Oct 31, 2000·The Journal of General Physiology·N ZilberbergS A Goldstein
Feb 3, 1999·Annals of the New York Academy of Sciences·D J Baro, R M Harris-Warrick
Jul 22, 1999·Annals of the New York Academy of Sciences·Z W WangL Salkoff
Mar 22, 2006·BMC Evolutionary Biology·David A FitzpatrickAnn M Burnell
Oct 19, 2000·Journal of Basic and Clinical Physiology and Pharmacology·M Perouansky, R A Pearce
Dec 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bojun ChenZhao-Wen Wang
Jan 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patricio RojasLawrence Salkoff
Feb 16, 2002·The Japanese Journal of Physiology·J F NoulinJ Y Lapointe
Nov 5, 1997·Archives of Biochemistry and Biophysics·J D WadsworthP N Strong
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alexandra S MartinsonTimothy Jegla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.