Eight-year results of a prospective non-randomised study on therapy of small breast cancer. The German Breast Cancer Study Group (GBSG)

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
H F RauscheckerM Schumacher

Abstract

In this report, the results of the first controlled clinical trial on breast cancer in Germany, begun in 1983, are presented after a median follow-up of 8 years. Four-year results have been previously published. In pT1 N0 M0 breast cancer, mastectomy as the standard treatment was to be compared with tumorectomy plus radiotherapy to the remaining breast tissue. The study design, originally planned as a comprehensive cohort study including randomised and non-randomised patients, had to be changed into a prospective observation study due to the low randomisation rate. 1036 out of 1119 recruited patients were evaluable. After a median follow-up of 97 months, 237 events (local recurrence, regional recurrence, distant metastases, contralateral breast cancer or death of the patient without previous recurrence) occurred. With the exception of death without recurrence, the events were evenly distributed among the two treatment groups. The 8-year local recurrence rate of the whole patient population is 8.8%. Out of all prognostic factors examined, only tumour size and grade had a significant influence on recurrent disease. Event-free survival decreased in cases with 'uncertain' tumour margins, whereas the width of the margin has no influ...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·R SauerD Marx
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J A van DongenJ Winter
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L C VerhoefW A van Daal
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U VeronesiP Squicciarini
Mar 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D SarrazinJ Lacour
Nov 15, 1995·Journal of the National Cancer Institute·M MorrowS J Schnitt
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U VeronesiF Rilke
Dec 20, 1995·Journal of the National Cancer Institute·J S AbramsM A Friedman
Jan 1, 1993·Breast Cancer Research and Treatment·M SchumacherH Rauschecker
Feb 1, 1996·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S C RentonR Sutcliffe

❮ Previous
Next ❯

Citations

Jul 29, 2010·Breast Cancer Research and Treatment·Elrasheid A H KheirelseidMichael J Kerin
Apr 20, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K-J WinzerUNKNOWN German Breast Cancer Study Group
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R ReitsamerH Kogelnik
Mar 28, 2012·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Janet P EdwardsAndrew J Graham
Sep 8, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nehmat HoussamiLawrence J Solin
Nov 3, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K-J WinzerUNKNOWN German Breast Cancer Study Group (GBSG)
Nov 1, 2001·The Cochrane Database of Systematic Reviews·H RauscheckerA Recht
Nov 5, 1999·Current Opinion in Oncology·F Asrari, I Gage
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C SchmoorM Schumacher
Sep 11, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·James BundredNigel Bundred

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.