Eisenia bicyclis (brown alga) modulates platelet function and inhibits thrombus formation via impaired P2 Y12 receptor signaling pathway

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Muhammad IrfanMan Hee Rhee

Abstract

Sea weeds have been used since ancient times in Asian countries, especially in Korea, Japan, and China, as both edible sea vegetables and traditional medicinal tonics due to their health benefits. Eisenia bicyclis has been studied for anti-allergic and anti-cancer effects; however, its effects on the cardiovascular system, especially on platelet function, are yet to be explored. Therefore, we examined the effect of E. bicyclis on platelet function. E. bicyclis extract (EBE) was prepared and in vitro effects on ADP-induced platelet aggregation, granule secretion, intracellular calcium ion ([Ca2+]i) mobilization, fibrinogen binding to integrin αIIbβ3 and clot retraction were evaluated. Phosphorylation levels of MAPK signaling molecules and P2Y12 receptor downstream signaling pathway components were studied. In vivo effects were studied using an arteriovenous (AV) shunt model. EBE markedly inhibited in vitro ADP-induced platelet aggregation, granule secretion (ATP release and P-selectin expression), [Ca2+]i mobilization, fibrinogen binding to integrin αIIbβ3, and clot retraction; attenuated MAPK pathway activation; and inhibited phosphorylation of PI3K/Akt, PLCγ2, and Src. The extract significantly inhibited in vivo thrombus weigh...Continue Reading

Citations

Sep 4, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Bo-Ra JeonMan Hee Rhee
Mar 25, 2020·BMC Complementary Medicine and Therapies·Dahye JeongMan Hee Rhee
Oct 18, 2020·Marine Drugs·Rohini Dwivedi, Vitor H Pomin
May 7, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Muhammad IrfanMan Hee Rhee
Sep 22, 2021·Chinese Journal of Integrative Medicine·Bo-Ra JeonMan Hee Rhee

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