Ejaculatory dysfunction caused by the new alpha1-blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography

International Journal of Urology : Official Journal of the Japanese Urological Association
Atsushi NagaiYoshiyuki Miyaji

Abstract

In order to clinically investigate the mechanism of ejaculatory dysfunction attributable to the alpha1-blocker silodosin, a real-time observation of ejaculation by healthy males was performed. Following intake of silodosin, a newly developed selective alpha1-blocker for benign prostatic hypertrophy, ejaculation was dynamically observed using color Doppler ultrasound in three healthy males. Normal ejaculation was also investigated in the same manner. With silodosin intake, no antegrade ejaculation was observed in cases 1 or 2. In case 1, seminal fluid slowly but continuously flowed out from the seminal vesicles into the bladder. In case 2, only a small amount of seminal fluid flowed into the bladder during the ejaculatory sensation. In case 3, ejection of a small amount of semen from the external urethral orifice was observed and inflow of a small amount of seminal fluid into the bladder was also captured. Without silodosin intake, all three subjects exhibited antegrade ejaculation. The mechanism of ejaculatory dysfunction is intricately related to retrograde ejaculation (retrograde inflow of seminal fluid), insufficient contraction of the seminal vesicles, and insufficient rhythmic contraction of the muscles of the pelvic floor.

References

Apr 1, 1994·British Journal of Urology·J M Gil-VernetJ M Gil-Vernet
Aug 1, 1995·The Journal of Pharmacy and Pharmacology·H SadraeiI E Hughes
Jan 13, 2006·The Journal of Urology·Serdar GoktasBedrettin Seckin
Mar 7, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tomoji ShimizuMasayuki Yamaguchi
Aug 2, 2006·BJU International·François A GiulianoJacques Bernabé
Sep 6, 2006·The Journal of Urology·Wayne J G Hellstrom, Suresh C Sikka
Oct 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Shin-ichi HisasueTaiji Tsukamoto

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Citations

May 15, 2010·Current Urology Reports·Herbert J Wiser, Tobias S Köhler
Oct 16, 2012·Current Urology Reports·John Roger Bell, Eric Laborde
Jun 19, 2009·International Journal of Impotence Research·T A Skolarus, J T Wei
Jun 19, 2009·International Journal of Impotence Research·K KobayashiT Tsukamoto
Aug 15, 2014·Current Urology Reports·Charles WelliverKevin T McVary
Jan 29, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Teruhiko YokoyamaAtsushi Sone
Jan 15, 2010·The Annals of Pharmacotherapy·Matthew A CantrellJames S Magera
Oct 15, 2019·Reproductive Medicine and Biology·Toshikazu Otani
Apr 1, 2015·Postgraduate Medicine·David MobleyNeil Baum
Oct 10, 2018·IJU Case Reports·Ryoei HaraYoshiyuki Miyaji
Mar 13, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Francesco MontorsiCarlos Llorente
Dec 23, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshikazu SatoIchiya Honma
Mar 27, 2015·International Journal of Urology : Official Journal of the Japanese Urological Association·Ryoei HaraYoshiyuki Miyaji
Aug 1, 2016·The Urologic Clinics of North America·Charles Welliver, Ahmed Essa
Aug 12, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumisato MaesakaKiyohide Fujimoto

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