PMID: 2498069May 1, 1989Paper

El mouse as a model of focal epilepsy: a review

Epilepsia
J T King, C C LaMotte

Abstract

The El mouse is a model of hereditary sensory precipitated temporal lobe epilepsy. All adult El mice given rhythmic vestibular stimulation (e.g. tossing, rocking) during development will experience tonic-clonic convulsions when given similar stimulation as adults. The seizures have prodromal, convulsive, and postictal stages. EEG and 2-deoxyglucose studies have localized the seizures to the temporal lobe, with onset in the hippocampus. El mice have a decreased threshold for convulsion by electrical or pharmacologic stimulation. A variety of anticonvulsant medications eliminate El mouse seizures, including phenytoin (PHT), phenobarbital (PB), valproate (VPA), and ethosuximide (ESM). Anatomic studies have shown subtle differences in the thalamus and hippocampus of El mice. Immunohistochemistry of the El mouse hippocampus has revealed changes in peptidergic and gabaergic cell populations. Numerous biochemical differences have been found between El and nonconvulsive mice, including increased acetylcholine (ACh), dopamine (DA), GABA, serotonin (5-HT), and decreased norepinephrine (NE).

References

Jun 1, 1975·Electroencephalography and Clinical Neurophysiology·W J Loskota, P Lomax
Sep 1, 1977·Electroencephalography and Clinical Neurophysiology·J Suzuki, Y Nakamoto
May 1, 1975·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·T HataT Kita
Jan 1, 1986·Epilepsia·M P Remler, W H Marcussen
Mar 1, 1985·Epilepsia·T N Seyfried, G H Glaser
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·E C Crichlow, R D Crawford
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Dec 1, 1970·Brain Research·H Shinozaki, S Konishi
Sep 1, 1970·The Journal of Heredity·R D Crawford
Jan 1, 1966·Progress in Brain Research·M KurokawaM Kato
Sep 1, 1984·Brain : a Journal of Neurology·E K Warrington, T Shallice
Sep 1, 1983·Neurochemical Research·M Hiramatsu
Jun 1, 1984·Brain : a Journal of Neurology·K M HeilmanR T Watson
Feb 1, 1982·Experimental Neurology·J Suzuki, Y Nakamoto
Mar 1, 1981·Neurochemical Research·M Hiramatsu, A Mori
Jun 24, 1961·Biochimica Et Biophysica Acta·M KUROKAWAY MACHIYAMA
Jun 1, 1961·Electroencephalography and Clinical Neurophysiology·B BLUME LIBAN
Jul 1, 1962·Journal of Applied Physiology·J G CHUSID, L M KOPELOFF
Jul 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·L M KOPELOFF
Jun 1, 1960·Journal of Neurochemistry·H NARUSET YABE

❮ Previous
Next ❯

Citations

Feb 1, 1996·Synapse·M S Starr
Mar 1, 1993·Electroencephalography and Clinical Neurophysiology·K MutohH Mikawa
Dec 17, 1991·Brain Research. Developmental Brain Research·T MitaH Hirano
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Eric SouthamPhilip F Morgan
Dec 3, 1999·Brain Research. Molecular Brain Research·Y Yamada, K Nakano
Jan 4, 2001·Neurochemistry International·T MitaK Shibata
Sep 28, 2002·Epilepsy Research·Maki HirateNaoto Oku
Dec 28, 1999·Epilepsia·M T TodorovaT N Seyfried
Sep 22, 2000·Epilepsia·Y L MurashimaJ Suzuki
Jul 1, 2005·Epilepsia·Yoshiya L MurashimaMitsunobu Yoshii
May 3, 2006·Epilepsia·Melanie P Leussis, Stephen C Heinrichs
Jun 5, 2014·Epilepsy Research·Daisuke HasegawaMichio Fujita
Apr 29, 1998·Current Opinion in Neurology·R C Scott, B G Neville
Jan 29, 2013·Epilepsy Research·Arnaud BoissonnetJean-François Cloix
May 15, 2002·Brain Research. Molecular Brain Research·Yukinori NakagawaKiwao Nakano
Jul 16, 2008·Brain Research·Mayuko TakakiHiroshi Kannan
May 8, 2007·Neuroscience Research·Mayuko TakakiHiroshi Kannan
Jan 12, 2007·Epilepsy Research·Alyssa Richman, Stephen C Heinrichs
Jan 6, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jarogniew J Luszczki, Stanislaw J Czuczwar
Nov 16, 2004·Annals of the New York Academy of Sciences·Yurie NakamotoMitsunobu Yoshii
Nov 19, 2004·Brain Research. Molecular Brain Research·Izumi YawataKiwao Nakano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.