Elaboration of a national biobank for the study of gestational trophoblastic diseases

Journal de gynécologie, obstétrique et biologie de la reproduction
P-A BolzeF Golfier

Abstract

To generate a national biobank made up of samples of the highest quality for the purpose of inciting basic research on gestational trophoblastic diseases (GTD). Three priority axes of research were defined to optimize the nature, method of collection, and storage of the samples. These are: to enhance our understanding of GTD, develop new diagnostic tests, and identify new therapeutic targets. The protocol for patient inclusion and sample processing was determined after extensive literature review and collaboration with international experts in the field of GTD. For each patient with a GTD and for control patients (legally induced abortions), chorionic villi, decidua and tumor samples (fresh, immersed in RNA-protective solution and fixed in formaldehyde), blood (serum, plasma, RNA, and peripheral blood mononuclear cells), urine (supernatant), and cell cultures of villous cytotrophoblasts are prospectively collected. Associations are then made between the collected samples and numerous clinical and biological data, such as human chorionic gonadotropic plasma levels following curettage in the case of a hydatidiform mole. Such a collection of high quality samples and their associated data open up new perspectives for both national ...Continue Reading

References

Aug 27, 2010·American Journal of Obstetrics and Gynecology·John R Lurain
Aug 16, 2011·Human Reproduction·Francois GolfierDaniel Raudrant
Dec 13, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Constantine AlifrangisMichael J Seckl
Dec 25, 2012·Placenta·G J BurtonV Clifton
Dec 3, 2013·Placenta·G J BurtonC W Redman
Dec 17, 2014·Annales de pathologie·Fabienne AlliasUNKNOWN réseau des maladies trophoblastiques gestationnelles

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