Elaboration of Bacillus anthracis antigens in a new, defined culture medium.

Infection and Immunity
J D Ristroph, B E Ivins

Abstract

Improved culture conditions and a new, completely synthetic medium (R medium) were developed to facilitate the production of Bacillus anthracis holotoxin antigens. Levels of these antigens up to fivefold greater than the highest previously reported values were recovered with the described system. Cultures of Sterne, V770-NP1-R, and Vollum 1B strains of B. anthracis were monitored for growth, pH change, glucose utilization, supernatant protein concentration, lethal toxin activity, and protease activity.

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Citations

May 1, 1989·The Journal of Applied Bacteriology·A P Phillips, J W Ezzell
Dec 1, 1988·FEMS Microbiology Immunology·A P PhillipsR Quinn
Mar 18, 2000·Infection and Immunity·F BrossierJ C Sirard
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Sep 14, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alice ChâteauAgnès Fouet
Oct 7, 2015·Infection and Immunity·Chinh T Q NguyenAnthony W Maresso
Nov 3, 2010·Infection and Immunity·Amy JenkinsSusan Welkos
May 13, 2015·Journal of Bacteriology·Austen TerwilligerAnthony Maresso
Jun 18, 2017·Annual Review of Microbiology·Dominique Missiakas, Olaf Schneewind
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