PMID: 6977557Mar 1, 1982Paper

Elaboration of type b capsule by Haemophilus influenzae as a determinant of pathogenicity and impaired killing by trimethoprim-sulfamethoxazole

The Journal of Clinical Investigation
R Yogev, E R Moxon

Abstract

In vitro, Haemophilus influenzae strains have two distinct patterns of susceptibility to trimethoprim-sulfamethoxazole (TMP/SMZ); strains with low minimum inhibitory concentration and high minimum bactericidal concentration (tolerant) and those with both low minimum inhibitory concentration and minimum bactericidal concentration (kill-sensitive). Tolerant H. influenzae strains were found to elaborate significantly more type b capsular polysaccharide, a linear polymer of ribosyl ribose phosphate (PRP), than kill-sensitive strains. Tolerant strains became susceptible to killing by TMP/SMZ when type b capsule was physically removed, but reacquired tolerance following growth and reversion to original (mucoid) phenotype. Susceptibility of wild (type a, b, c), isogenic (type b and untypable), and transformed (type b and d) strains indicated that elaboration of type b capsule was associated with TMP/SMZ tolerance. In a second series of studies, virulence of H. influenzae in the infant rat model was correlated with in vitro tolerance. Tolerant strains (13/13) caused systemic disease while none (0/7) of kill-sensitive strains were pathogenic. The efficacy of TMP/SMZ in the treatment of invasive infection was evaluated in rats with estab...Continue Reading

References

Jan 1, 1977·The Journal of Infectious Diseases·P F WellerD H Smith
Aug 15, 1977·JAMA : the Journal of the American Medical Association·C M GinsburgJ C Parke
May 1, 1979·The Journal of Pediatrics·R YogevA T Davis
Jul 19, 1979·The New England Journal of Medicine·J I WardB D Plikaytis
May 1, 1978·The Journal of Pediatrics·J I WardD W Fraser
May 1, 1975·Pediatric Research·R H MichaelsJ B Robbins
Jan 1, 1972·The Journal of Clinical Investigation·P AndersonD H Smith

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Citations

Jun 1, 1984·European Journal of Clinical Microbiology·F R Sattler, J S Remington

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