PMID: 7932021Jul 1, 1994Paper

Elastase and lactoferrin in gingival crevicular fluid: possible indicators of a granulocyte-associated specific host response

Journal of Periodontal Research
A GustafssonK Bergström

Abstract

Periodontitis affects a limited number of susceptible humans. The aim of this study was to determine whether there is a difference in the inflammatory reaction between patients with gingivitis and those with periodontitis. For this purpose the levels of elastase and lactoferrin were measured in gingival crevicular fluid (GCF) from three types of sites: i) inflamed sites in patients with gingivitis alone, inflamed sites both ii) with and iii) without tissue destruction in patients with periodontitis. Elastase activity, measured with a chromogenic substrate was significantly higher in the two types of sites in periodontitis patients. Lactoferrin levels, measured with ELISA were the same in the three types of sites. In vitro activation of granulocytes from healthy volunteers with Fc-receptor stimulation showed that the entire release of lactoferrin occurred immediately. In contrast, elastase release was time-dependent and continued throughout the experiment. Thus, the degranulation of the specific (lactoferrin) and azurophil granule (elastase) are under separate control and the two parameters can be combined in a ratio in order to characterize the granulocytes of a given patient. Assuming an immediate release of lactoferrin from t...Continue Reading

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Citations

Jan 1, 1997·Journal of Dentistry·I L Chapple
Aug 15, 2002·Clinical Oral Implants Research·Margareta HultinBjörn Klinge
Jan 6, 2001·Journal of Clinical Periodontology·J M HerrmannJ Meyle
Feb 1, 1996·Journal of Clinical Periodontology·T TervahartialaT Sorsa
May 30, 1998·Journal of Clinical Periodontology·C M Figueredo, A Gustafsson
Aug 8, 1998·Journal of Clinical Periodontology·C M Figueredo, A Gustafsson
Nov 1, 1996·Annals of Periodontology·G C Armitage
Sep 15, 1998·Journal of Periodontology·K T MiyasakiS Underwood
Feb 24, 2001·Journal of Periodontology·L PerssonA Gustafsson
Dec 5, 2003·Journal of Periodontology·Lena PerssonAnders Gustafsson
Mar 4, 2006·Journal of Periodontology·Jörg EberhardJens M Schröder
May 11, 2010·Journal of Periodontology·Bruno RescalaCarlos Marcelo Figueredo
Dec 15, 2015·Periodontology 2000·Silvana P BarrosThiago Morelli
May 20, 2003·Journal of Periodontal Research·Lijian JinEsmonde F Corbet
Apr 4, 2007·Clinical and Experimental Immunology·L ShenC R Wira
Jun 11, 2014·Australian Dental Journal·N YadavP Pahwa
Jun 28, 2005·Dental Clinics of North America·Mario TabaWilliam V Giannobile
Mar 27, 2003·Periodontology 2000·Andrew J Delima, Thomas E Van Dyke
Mar 27, 2003·Periodontology 2000·Veli-Jukka UittoCristopher McCulloch
Oct 25, 2016·Journal of Periodontology·Hiroshi ItoKazushi Kunimatsu
Jan 14, 2004·Periodontology 2000·Gary C Armitage
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Sep 1, 1995·Journal of Periodontal Research·R S GomezV C de Araújo
Nov 3, 2020·Journal of Oral Microbiology·Katharina EnigkCatalina-Suzana Stingu

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