PMID: 8467766Mar 1, 1993Paper

Elastase causes secretory discharge in bronchi of hamsters with elastase-induced secretory cell metaplasia

Experimental Lung Research
R BreuerG L Snider

Abstract

A single intratracheal instillation of human neutrophil elastase (HNE) into hamsters causes granule discharge from bronchial secretory cells followed by marked accumulation of granules, visible by light microscopy at 21 days and persisting through 18 months. To determine whether persistence of this secretory cell metaplasia (SCM) is due to inability of the metaplastic secretory cells to secrete their granules, hamsters having HNE-induced SCM were challenged with the potent secretagogue HNE. Four groups of 10 hamsters each received 300 micrograms HNE intratracheally. Twenty-one days later, hamsters were intratracheally treated with HNE or saline; the groups were designated HNE-HNE and HNE-SAL, respectively. Hamsters were killed 2 h or 21 days following the second treatment. Using light microscopy, nucleated epithelial cells were counted in plastic sections of the left main intrapulmonary bronchus. Cells were classified as ciliated (C), basal (B), indeterminate (IN), or secretory. Secretory cells were subcategorized as S0 (0 granules), S1 (1-4 granules), S2 (> or = 5 granules with intervening cytoplasm), and S3 (abundant granules completely filling the cytoplasm). At 2 h, S3 cell frequency in the HNE-HNE group was 13.0 +/- 2.2 (%...Continue Reading

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Citations

Jul 31, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·L NikasinovicN Seta
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·H Y ChoJ R Harkema
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Thomas FerkolPamela B Davis
Jun 9, 2007·American Journal of Respiratory and Critical Care Medicine·James C HoggFrank C Sciurba
May 1, 1993·American Journal of Respiratory Cell and Molecular Biology·R BreuerG L Snider
May 8, 2010·The Open Respiratory Medicine Journal·Derek J QuinnClifford C Taggart
Jan 28, 2014·Respiratory Physiology & Neurobiology·Luiz Marcelo Oliveira SantosRoseli Soncini
Aug 12, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Jack R Harkema, James G Wagner
Jul 17, 1999·Toxicology and Applied Pharmacology·H Y ChoJ R Harkema
Dec 14, 2011·Anais Da Academia Brasileira De Ciências·Mariana A Antunes, Patricia R M Rocco
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J M DrazenS A Shore

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