PMID: 9529060Apr 7, 1998Paper

Elastase is the only human neutrophil granule protein that alone is responsible for in vitro killing of Borrelia burgdorferi

Infection and Immunity
R GarciaG D Rottini

Abstract

Phagocytosis of Borrelia burgdorferi by human polymorphonuclear leukocytes triggers oxygen-dependent and -independent mechanisms of potentially cidal outcome. Nevertheless, no factor or process has yet been singled out as being borreliacidal. We have studied the B. burgdorferi-killing ability of the myeloperoxidase-H2O2-chloride system and that of primary and secondary granule components in an in vitro assay. We found that neither secondary granule acid extracts nor the chlorinating system could kill these microorganisms, while primary granule extracts were effective. The Borrelia-killing factor was purified to homogeneity and demonstrated to be elastase. Its cidal activity was found to be independent of its proteolytic activity.

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Citations

Nov 20, 2002·Infection and Immunity·Rossella MurgiaMarina Cinco
Dec 16, 2011·Immunological Reviews·Robert I Lehrer, Wuyuan Lu
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mario PausaFrancesco Tedesco
May 3, 2005·Nature Reviews. Microbiology·Sean E Connolly, Jorge L Benach
Sep 14, 2007·Immunological Reviews·William M Nauseef
Nov 16, 2007·Clinical and Vaccine Immunology : CVI·Dean T NardelliRonald F Schell
May 23, 2006·Infection and Immunity·Philip E StewartPatricia A Rosa
Nov 15, 2006·Infection and Immunity·Ruth R MontgomeryCharles R Brown
Feb 10, 2006·Clinical and Vaccine Immunology : CVI·Corey A AmlongRonald F Schell
Mar 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chang-Won HongDong-Keun Song
Mar 23, 2006·Infection and Immunity·Ruth R MontgomeryStephen E Malawista
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·T M Dwyer, J M Farley
Jun 11, 2015·Kidney International·Uwe JerkeRalph Kettritz

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