PMID: 1213975Dec 1, 1975Paper

Elastic behavior of postmortem human lungs: effects of aging and mild emphysema

Journal of Applied Physiology
D E NiewoehnerL Liotta

Abstract

The elastic behavior of postmortem human lungs has been studied in an effort to differentiate the effects of normal aging from those of mild emphysema. Static pressure-volume (P-V) curves were measured in 50 lungs obtained from men 15-85 yr of age, including 12 lungs with mild-to-moderate emphysema. The emphysema was quantitatively assessed by gross and microscopic methods. The P-V relationship in all lungs is accurately described by the empirically fitted equation, P = alpha1ea2v. This expression is useful because the two parameters separate the effects of elastic behavior (alpha1) from size (alpha2) on the P-V curve. There is a close negative correlation (R = -0.94) Between age and alpha1 in normal lungs but no significant age dependence of alpha2. Further decreases in alpha1 are found in most emphysematous lungs. Alpha1 is more than 2 SEE below the age-predicted mean in five of nine lungs with minimal emphysema (1-10% by point count) and more than 5 SEE below the mean in the three more severely affected lungs. There is a close correlation (R = +0.90) between alpha1 and the alveolar surface-to-volume ratio in both normal and emphysematous lungs.

Citations

Jul 1, 1980·Thorax·G W SilversR E Stanford
May 11, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Parya AghasafariRamana M Pidaparti
Mar 8, 2019·Scientific Reports·Yeon Wook KimSang-Do Lee
May 1, 1984·The American Journal of Anatomy·M KawakamiW M Thurlbeck
Jan 29, 2000·The Annals of Otology, Rhinology, and Laryngology·S D GrayT H Hammond
Jan 1, 1984·Journal of Toxicology and Environmental Health·W M Thurlbeck
Jul 1, 1985·Pediatric Pulmonology·M Saetta, J P Mortola
Nov 14, 2012·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Bruno HochheggerEduardo Garcia
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·C Perez-GuzmanM H Vargas
Jul 13, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rungchai ChaunchaiyakulNigel A S Taylor
May 19, 2006·Rejuvenation Research·Vincent M Monnier, David R Sell
Aug 27, 2016·American Journal of Respiratory and Critical Care Medicine·Carlos H MartinezUNKNOWN SPIROMICS Investigators
Jul 23, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Victoria S McKenna, Jessica E Huber
Jan 1, 1990·Experimental Gerontology·J S KerrD J Riley
Aug 5, 2000·Otolaryngologic Clinics of North America·S D Gray
Aug 1, 1988·Chest·M Demedts, J Aumann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved