PMID: 15244842Jul 13, 2004Paper

Elastic deformations of grafted layers with surface stress

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
A Nicolas, Samuel A Safran

Abstract

We calculate the elastic response of thin films grafted to a solid substrate whose upper surface is subject to a stress. This issue is addressed in the context of biological cell adhesion where adhesive junctions consist of a thin layer of proteins grafted to the extracellular matrix and sheared by the cell contractility apparatus. We show that the finite thickness of the layer limits stress-induced deformations to short ranges proportional to the thickness of the film. In addition, we show that the attachment boundary condition creates an effective shear response to surface stresses that couples all the directions, even for fluidlike layers. We predict that perturbations with wavelengths of order of the film thickness induce resonancelike responses for isotropic rubberlike materials or anisotropic media with high shear moduli. We use these results to predict the elastic deformations of a layer of proteins under shear stress and propose that the resulting, polarized elastic response to local surface forces can explain the observed, anisotropic growth of cell-substrate junctions when subject to external stresses.

References

Jun 27, 2000·Biophysical Journal·C M LoY L Wang
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Oct 3, 2001·Physical Review Letters·M BowickA Travesset
Nov 21, 2001·Nature Reviews. Molecular Cell Biology·B GeigerK M Yamada
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Citations

Jun 14, 2005·Medical Engineering & Physics·Ulrich S Schwarz, Ilka B Bischofs
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alice NicolasSamuel A Safran
Sep 2, 2010·PloS One·Joseph E OlberdingKrishna Garikipati
Mar 4, 2006·Biophysical Journal·Achim Besser, Samuel A Safran
Apr 4, 2006·Biophysical Journal·Alice Nicolas, Samuel A Safran
Oct 21, 2005·Bio Systems·Ulrich S SchwarzIlka B Bischofs
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·A Sarasa-Renedo, M Chiquet
Mar 14, 2014·Soft Matter·Michel MoussusAlice Nicolas
Dec 9, 2020·Soft Matter·Haiqin Wang, Xinpeng Xu
Mar 5, 2020·Computational and Structural Biotechnology Journal·Laurent MacKay, Anmar Khadra
Jun 24, 2018·Biochimica Et Biophysica Acta. Biomembranes·Kent Shilts, Christoph A Naumann
Oct 18, 2011·Journal of Colloid and Interface Science·Jianyong HuangJing Fang

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Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

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