Elastic energy storage in unmineralized and mineralized extracellular matrices (ECMs): a comparison between molecular modeling and experimental measurements

Journal of Theoretical Biology
Joseph W Freeman, Frederick H Silver

Abstract

In order to facilitate locomotion and limb movement many animals store energy elastically in their tendons. In the turkey, much of the force generated by the gastrocnemius muscle is stored as elastic energy during tendon deformation and not within the muscle. As limbs move, the tendons are strained causing the collagen fibers in the extracellular matrices to be strained. During growth, avian tendons mineralize in the portions distal to the muscle and show increased tensile strength, modulus, and energy stored per unit strain as a result. In this study the energy stored in unmineralized and mineralized collagen fibers was measured and compared to the amount of energy stored in molecular models. Elastic energy storage values calculated using the molecular model were slightly higher than those obtained from collagen fibers, but display the same increases in slope as the fiber data. We hypothesize that these increases in slope are due to a change from the stretching of flexible regions of the collagen molecule to the stretching of less flexible regions. The elastic modulus obtained from the unmineralized molecular model correlates well with elastic moduli of unmineralized collagen from other studies. This study demonstrates the pot...Continue Reading

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Citations

Apr 30, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Ewa M Spiesz, Philippe K Zysset
Aug 13, 2013·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Daniel LambertzKarla M Ferraz
Nov 29, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·R G ShahF H Silver
Oct 7, 2016·Physical Chemistry Chemical Physics : PCCP·Carmen DomeneSumra Wajid Abbasi
Jun 17, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Christopher Lee Organ
Nov 20, 2010·Chemical Communications : Chem Comm·Honorius M H F SandersNico A J M Sommerdijk
Oct 30, 2007·Biomacromolecules·August J HeimWilliam G Matthews

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